Multimodal image-guided laser ablation system for precise 3D tissue sampling and subsequent analysis of biomolecules in cancer research

Jan Hahn; Manuela Moritz; Anton Walter; Tamara Wieck; Ayham Moustafa; Wael Y. Mansour; Charlotte Harms; Peter Stenzel; Jörg Heeren; Marie-Therese Haider; Tobias Lange; Hartmut Schlüter

doi:10.1117/12.3003707

12 March 2024 Multimodal image-guided laser ablation system for precise 3D tissue sampling and subsequent analysis of biomolecules in cancer research

Jan Hahn, Manuela Moritz, Anton Walter, Tamara Wieck, Ayham Moustafa, Wael Y. Mansour, Charlotte Harms, Peter Stenzel, Jörg Heeren, Marie-Therese Haider, Tobias Lange, Hartmut Schlüter

Author Affiliations +

Proceedings Volume 12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII; 128460C (2024) https://doi.org/10.1117/12.3003707
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We demonstrate an early-stage prototype of an image-guided laser ablation system for precise 3D sampling of fresh-frozen tissue samples for subsequent analysis of biomolecules. Utilizing an integrated reflected light microscope and optical coherence tomography, pre-recorded image data (e.g. of characterized tissue slices) can be registered and mapped to the coordinate system for precise aiming and ablation. With this system, we are analyzing a variety of tissue samples from our many collaborators at the University Cancer Center Hamburg (UCCH) for cancer research and demonstrate the system’s feasibility through initial use cases.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jan Hahn, Manuela Moritz, Anton Walter, Tamara Wieck, Ayham Moustafa, Wael Y. Mansour, Charlotte Harms, Peter Stenzel, Jörg Heeren, Marie-Therese Haider, Tobias Lange, and Hartmut Schlüter "Multimodal image-guided laser ablation system for precise 3D tissue sampling and subsequent analysis of biomolecules in cancer research", Proc. SPIE 12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII, 128460C (12 March 2024); https://doi.org/10.1117/12.3003707

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available