HELLS: a novel prognostic marker for patients with different subtypes of cervical cancer

Jiaqi Zhang

doi:10.1117/12.2669969

24 March 2023 HELLS: a novel prognostic marker for patients with different subtypes of cervical cancer

Jiaqi Zhang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126111I (2023) https://doi.org/10.1117/12.2669969
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Cervical cancer is one of the malignant tumors that threaten the lives of women all over the world. Improving the early diagnosis of cervical cancer is particularly important for the prevention and treatment of cervical cancer. In this study, we used a large sample database to analyze molecules associated with cervical cancer survival and found that HELLS was negatively correlated with cervical cancer prognosis. At the same time, HELLS was highly expressed not only in cervical cancer but also in many other tumor tissues in the pan-cancer analysis. This suggests that HELLS may be a poor prognostic factor in tumors and further stratified analysis found that the effects of HELLS on the prognosis of cervical cancer limited to patients with TP53 mutated or moderated to low grade. As a result, HELLS, as a molecule involved in epigenetic regulation, mTOR signaling, and apoptosis pathway, is an unfavorable factor in the prognosis of cervical cancer patients, and can be used as tumor markers to indicate early diagnosis.

Citation Download Citation

Jiaqi Zhang "HELLS: a novel prognostic marker for patients with different subtypes of cervical cancer", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126111I (24 March 2023); https://doi.org/10.1117/12.2669969

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