Prolongation of tetrodotoxin’s anesthetic effect

Linghang Qu; Sian Xue; Qiwen Zhang

doi:10.1117/12.2668984

24 March 2023 Prolongation of tetrodotoxin’s anesthetic effect

Linghang Qu, Sian Xue, Qiwen Zhang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261159 (2023) https://doi.org/10.1117/12.2668984
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Tetrodotoxin (TTX) is a dangerous neurotoxin, where its toxicity is due to its highly specific binding and inhibition of sodium ion channels. Because the blocking sodium ion channels could inhibit the transmission of pain, TTX is a candidate for an anesthetic drug. Trials on rats and humans have shown that TTX has anesthetic ability with minimal adverse effects under 6 μg/Kg. It has short therapeutic window, but it is still a promising substitute of morphine. The performance could be improved with modifications such as covalent conjugation with a biodegradable polymer, combination with other chemicals such as, chemical permeation enhancers, epinephrine, or a low dose of morphine alone.

Citation Download Citation

Linghang Qu, Sian Xue, and Qiwen Zhang "Prolongation of tetrodotoxin’s anesthetic effect", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261159 (24 March 2023); https://doi.org/10.1117/12.2668984

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