Benjamin Ecclestonehttps://orcid.org/0000-0003-1726-8161,1 Saad R. Abbasi,1 Kevan Bell,1 Deepak Dinakaran,2 Muba Taher,2 John Mackey,2 Parsin Haji Reza1
1Univ. of Waterloo (Canada) 2Univ. of Alberta (Canada)
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Nonmelanoma skin cancers (NSMC) are among the most common malignancies in the US today. Mohs micrograph surgery (MMS) is the gold standard for most NSMC. However, MMS is time-consuming as it employs frozen section analysis (FSA) for intraoperative assessment. Each FSA can require up to 60 minutes per excision. Using photoacoustic remote sensing (PARS™) we demonstrate first results of imaging tissue morphology on human skin with a non-contact reflection-mode method, enabling rapid label-free pathological assessment. These images are validated against toluidine blue stained sections. The authors believe the proposed method represents a vital step towards an in-situ assessment of NSMC.
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Benjamin Ecclestone, Saad R. Abbasi, Kevan Bell, Deepak Dinakaran, Muba Taher, John Mackey, Parsin Haji Reza, "Towards in-situ imaging of nonmelanoma skin cancers," Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 116180V (5 March 2021); https://doi.org/10.1117/12.2577900