Conformational Change During Modification Of Creatine Kinase By Iodoacetamide: A Resolution Enhanced FT-IR Analysis

Lin Yingzhang; Zhou Junmei; Xu Zhenhua; Wu Jinguang

doi:10.1117/12.969450

1 December 1989 Conformational Change During Modification Of Creatine Kinase By Iodoacetamide: A Resolution Enhanced FT-IR Analysis

Lin Yingzhang, Zhou Junmei, Xu Zhenhua, Wu Jinguang

Author Affiliations +

Proceedings Volume 1145, 7th Intl Conf on Fourier Transform Spectroscopy; (1989) https://doi.org/10.1117/12.969450
Event: Seventh International Conference on Fourier and Computerized Infrared Spectroscopy, 1989, Fairfax, VA, United States

Abstract

FTIR and Raman spectra, resolution enhanced by second derivative and deconvolution techniques, have been used for studying protein secondary structure 1,2. A subtle conformational changes related to solvent denaturation and chemical modification can be distinguished. It has been shown that Raman spectroscopy combined with second derivative techniques and hydrogen-deuterium isotopic exchange can be successfully applied to identify he subtle comformational differences in creative kinase(EC 2.7.3.2)3.

Citation Download Citation

Lin Yingzhang, Zhou Junmei, Xu Zhenhua, and Wu Jinguang "Conformational Change During Modification Of Creatine Kinase By Iodoacetamide: A Resolution Enhanced FT-IR Analysis", Proc. SPIE 1145, 7th Intl Conf on Fourier Transform Spectroscopy, (1 December 1989); https://doi.org/10.1117/12.969450

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