In vivo macro- and micro-Raman spectroscopy for clinical diagnosis and research applications (Conference Presentation)

Haishan Zeng

doi:10.1117/12.2551010

9 March 2020 In vivo macro- and micro-Raman spectroscopy for clinical diagnosis and research applications (Conference Presentation)

Haishan Zeng

Author Affiliations +

Proceedings Volume 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry; 1123606 (2020) https://doi.org/10.1117/12.2551010
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Raman spectroscopy is a powerful technique for biochemical composition analysis. The inherent weak signal makes it a great challenge for in vivo tissue analysis. We have developed a platform technology that meets the challenge. One of our systems measures Raman spectra from a macro-size (mm3) tissue volume using a proprietary technology to correct spectrograph image distortion, realized >16 S/N improvement. The macro-Raman system is capable of acquiring a spectrum from tissue in vivo in 1 s, facilitating practical clinical applications. Two application examples will be presented: non-invasive skin cancer detection and endoscopic lung cancer detection. The other system measures Raman from micro-size (um3) tissue volume. It provides confocal imaging monitoring in the whole micro-Raman acquisition period (20 s) to guarantee the measurement stayed on target. Application for non-invasive glucose measurement and for mechanism study of multiphoton phototermolysis therapy will be presented.

Conference Presentation

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Haishan Zeng "In vivo macro- and micro-Raman spectroscopy for clinical diagnosis and research applications (Conference Presentation)", Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 1123606 (9 March 2020); https://doi.org/10.1117/12.2551010

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KEYWORDS

In vivo imaging

Raman spectroscopy

Micro raman spectroscopy

Clinical research

Skin cancer

Tissue optics

Algorithm development

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