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3 October 2022 Elucidating mechanisms of cytoskeletal ensemble synergy using optical tweezers
Dana Reinemann
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Proceedings Volume PC12198, Optical Trapping and Optical Micromanipulation XIX; PC1219803 (2022) https://doi.org/10.1117/12.2634958
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States
Abstract
A challenge within the motor biophysics field is reconstituting a motor-filament environment that reflects physiological function. Many optical trapping studies of motor proteins employ a reductionist geometry of a single motor interacting with a single filament. These conformations do not accurately represent the structural architecture in which motors with crosslinking ability, such as myosins or mitotic kinesins, function. Thus, we engineered customizable “nanocells” of reconstituted protein assemblies to probe hierarchical cytoskeletal mechanics with high resolution using optical tweezers.
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Dana Reinemann "Elucidating mechanisms of cytoskeletal ensemble synergy using optical tweezers", Proc. SPIE PC12198, Optical Trapping and Optical Micromanipulation XIX, PC1219803 (3 October 2022); https://doi.org/10.1117/12.2634958
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KEYWORDS
Optical tweezers
Mechanics
Proteins
Molecular assembly
Biophysics
In vitro testing
Microfluidics
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