Color difference threshold is an important parameter to evaluate human color vision characteristic, which is of great significance for early diagnosis and inspection of ophthalmic disease. The test of color vision characteristics has experienced the process from qualitative to semi-quantitative to quantitative. Based on the analysis of existing color vision test methods, a new method is proposed by using three-integrating sphere system and specially made color modulators with optical modulation principle, which can generate required test targets of different luminance and color. Then an automated measurement system is established which can realize the color difference threshold measurement quantitatively. The output parameters can be precisely adjusted and achieved by real-time control, and be traceable to the existing luminance and color standards with metrological control. By metrological evaluation, the color coordinate repeatability is 0.0003 and reproducibility is 0.004 for color modulation, and the color difference repeatability is within 0.30 and reproducibility is not over 1.0 for color vision test targets generated. Experiments show that the measurement system can generate required color vision test targets and realize the color visual threshold measurement well. With the advantage of large color modulation range and adjustable test target, the system can meet test needs of personalized human color vision in many related scientific research fields.
The rebound tonometer is commonly used for measuring intraocular pressure in children and patients with limited mobility due to its small size, portability, and non-invasive nature. In order to ensure the accuracy of its measurements, ISO 8612:2009 "Ophthalmic instruments — Tonometers" mandates that it undergo a clinical human eye comparison test against the Goldmann tonometer, which is considered the “gold standard” for intraocular pressure measurement. Additionally, a transfer standard device is required to assess the consistency of measurements across similar tonometer products. These transfer standard devices, known as simulated eyes, mimic the structure of the human eye to varying degrees of complexity depending on the specific tonometer being tested. This paper presents several solutions for rebound tonometer transfer standard device, including a water column simulated eye, a discrete rubber simulated eye, and a PDMS pressure-adjustable simulated eye.The design principles and pressure regulation of each simulated eye are described. Furthermore, tests are conducted using two different brands of rebound tonometers, and the measurement results are compared. It is important to note that each simulated eye has its own advantages and disadvantages due to its inability to fully replicate all parameters of the human eye. Addressing issues such as traceability and the aging effect of materials is crucial in improving the accuracy and reliability of these simulated eyes.
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