Dr. Yuandong J. Li Profile

Dr. Yuandong J. Li

Research Fellow at University of Washington

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Author

Publications (16)

Proceedings Article | 7 March 2022 Presentation

Single input polarization sensitive optical coherence tomography for imaging depth-resolved collagen organizations

Peijun Tang, Ruikang Wang, Mitchell Kirby, Nhan Le, Yuandong Li, Nicole Zeinstra, G. Nina Lu, Charles Murry, Ying Zheng

Proceedings Volume PC11948, PC1194819 (2022) https://doi.org/10.1117/12.2612959

KEYWORDS: Coherence imaging, Polarization, Optical coherence tomography, Collagen, Visualization, Tissues, Skin, In vivo imaging, Imaging systems, Heart

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Proceedings Article | 7 March 2022 Presentation

Non-invasive assessment of diameter-dependent cutaneous vascular alterations with age using optical coherence tomography angiography

Takuma Hoshino, Yusuke Hara, Masato Ninomiya, Toyonobu Yamashita, Chika Katagiri, Motoki Oguri, Masako Katsuyama, Yuandong Li, Yuxuan Cheng, Nhan Le, Ruikang Wang

Proceedings Volume PC11934, PC119340K (2022) https://doi.org/10.1117/12.2612839

KEYWORDS: Blood vessels, Optical coherence tomography, Angiography, Testing and analysis, Skin, Blood circulation

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Proceedings Article | 5 March 2021 Presentation

OCT imaging of cerebral blood flow and hemodynamics in fully awake mouse

Yuandong Li, Ruikang Wang

Proceedings Volume 11630, 1163005 (2021) https://doi.org/10.1117/12.2578704

KEYWORDS: Hemodynamics, Cerebral blood flow, Optical coherence tomography, Optical recording, Velocimetry, Neurovascular coupling, Intrinsic optical signal imaging, Cranial windows, Capillaries, Bridges

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SPIE Journal Paper | 17 September 2020 Open Access

Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation

Adiya Rakymzhan, Yuandong Li, Peijun Tang, Ruikang Wang

JBO, Vol. 25, Issue 09, 096005, (September 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.9.096005

KEYWORDS: Hemodynamics, Reflectivity, Blood circulation, Optical coherence tomography, Brain, Tissue optics, Signal detection, Cranial windows, Capillaries, Tissues

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Proceedings Article | 15 March 2018 Presentation

OCT velocimetry reveals electrical-evoked temporal capillary hemodynamics in mouse cerebral cortex during functional activation (Conference Presentation)

Wei Wei, Yuandong Li, Ruikang Wang

Proceedings Volume 10493, 104930L (2018) https://doi.org/10.1117/12.2290590

KEYWORDS: Capillaries, Optical coherence tomography, Hemodynamics, Velocimetry, Cerebral cortex, Angiography, Blood, Statistical analysis, Image resolution, Temporal resolution

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The cerebral vascular system serves constant demand of neuronal activities in the brain. Neural activations are typically followed by immediate rise in local blood flow through neural-vascular coupling. Temporal dynamics and spatial redistribution of this hyperemia within the capillary bed play a deterministic role in oxygen diffusing capacity, however, the functional behavior of which remains poorly understood. Taking the advantages of the high spatiotemporal resolution of OCT velocimetry designed upon eigen-decomposition (ED) statistical analysis, we investigated the intrinsic capillary red blood cell (RBC) fluctuations within mouse cerebral cortex, representing as bandwidths of the RBC flow frequencies. The temporal hemodynamics before (rest) and during (activation) a bout of hindpaw electrical stimulations are accordingly analyzed to resolve alterations in capillary flow disturbance and its spatial distribution. In our experiment, the electrical stimulation provokes a temporal RBC fluctuation increase (rest: 16715 m/s; activation: 20516 m/s; P < 0.05) in the capillary bed located in hindpaw somatosensory cortex (HSC), as compared to the control (rest: 17020 m/s; activation: 16918 m/s; P > 0.05) ; accompanied with an increase in capillary RBC velocity (rest: 49640 m/s; activation: 61349 m/s; P < 0.05) in HSC, as compared to the control (rest: 54462 m/s; activation: 55868 m/s; P > 0.05). In addition, no significant difference was observed for the capillary vessel density in either HSC (rest: 0.390.02 m/s; activation: 0.370.01 m/s; P > 0.05) or control (rest: 0.360.02 m/s; activation: 0.370.02 m/s; P > 0.05). We conclude that neural activation evokes spatiotemporal redistribution of capillary hemodynamics regulated through instantaneous increments in flow disturbance and flow velocity, but involves no recruitment of reserved capillaries (no RBC transit path variation). Our demonstration shows the potential of OCT angiography for functional investigation and modeling of spatiotemporally coupled hemodynamics to neural activities.

Proceedings Article | 14 March 2018 Presentation

OCT angiography reveals age-related differences in cerebral blood flow of anesthetized mice (Conference Presentation)

Woo June Choi, Yuandong Li, Wei Wei, Ruikang Wang

Proceedings Volume 10493, 104930J (2018) https://doi.org/10.1117/12.2291096

KEYWORDS: Capillaries, Angiography, Optical coherence tomography, Cerebral blood flow, Blood, Tomography, Brain, Pathology, Sensors, Functional imaging

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Proceedings Article | 14 March 2018 Presentation

OCT Eigen decompensation based penetrating vessel mapping (Conference Presentation)

Wei Wei, Yuandong Li, Woo June Choi, Ruikang Wang

Proceedings Volume 10493, 104930F (2018) https://doi.org/10.1117/12.2290866

KEYWORDS: Cerebral cortex, Natural surfaces, Tissues, Alzheimer's disease, Particles, Optical coherence tomography, Angiography, Statistical analysis, Bridges, Molecular bridges

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Penetrating vessels bridge the mesh of communicating vessels on the surface of cortex with the subsurface microvascular bed that feeds the underlying neural tissue. The degeneration and dysfunction of penetrating vessels directly relates to Alzheimer’s disease, perceptual deficit, amnestic syndrome and stroke. Here we propose a cerebral penetrating vessel mapping approach based on eigen decompensation (ED) principle component analysis that is innovatively redesigned from optical coherence tomography (OCT) angiography. Ensemble complex OCT signals acquired through repeated A-scans first form a covariance matrix and then project into an eigenspace to represent frequency components of moving particles. The eigen representation of signals possesses several advantages over that in spatiotemporal domain: 1) the eigen components possess distinct statistical distributions for penetrating vessels, surface communicating vessels, vessel free regions, and territories occupied by enriched capillaries; 2) this approach is immune to tailing artifacts, enabling automatic decoupling of penetrating vessels from lateral vasculature networks. To describe the uniqueness of penetrating vessels as 2D parameter mapping, a second round of eigen analysis is applied to the eigen representations by taking each eigen component as an observation and distributions of the eigen components as features. In our datasets of mouse cerebral cortex, the eigen components mainly follow a subtle logistic distribution, statistically more significant than other features in terms of distribution spectral power (> 30 dB). While, the existence of vessel penetrating behavior locally breaks this distribution, assigning low transform probabilities to corresponding A-scans. Therefore, the transform coefficients inversely correlate to the vessel penetration and fully reveal the spatial morphology of penetrating vessels from projection view. This method allows for automatic statistical quantification of penetrating arterioles and ascending venules from large volume OCT angiography data, and accordingly contributes to the morphometric analysis of cortical microvasculature in functioning brains.

SPIE Journal Paper | 15 June 2017 Open Access

Optical coherence tomography angiography-based capillary velocimetry

Ruikang Wang, Qinqin Zhang, Yuandong Li, Shaozhen Song

JBO, Vol. 22, Issue 06, 066008, (June 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.6.066008

KEYWORDS: Optical coherence tomography, Capillaries, Blood circulation, Angiography, In vivo imaging, Statistical analysis, Tissues, Velocimetry, Particles, Scattering

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Proceedings Article | 19 April 2017 Presentation

Using OCT-based microangiography for in vivo longitudinal study of arteriogenesis (Conference Presentation)

Yuandong Li, Woo June Choi, Ruikang Wang

Proceedings Volume 10063, 100630F (2017) https://doi.org/10.1117/12.2253285

KEYWORDS: Cerebral cortex, Arteries, Blood circulation, Animal model studies, Image processing, In vivo imaging, Blood, Tissues, Ischemia, Vascular diseases

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Proceedings Article | 19 April 2017 Presentation

Effect of hindpaw electrical stimulation on capillary flow heterogeneity and oxygen delivery (Conference Presentation)

Yuandong Li, Wei Wei, Chenxi Li, Ruikang Wang

Proceedings Volume 10051, 1005102 (2017) https://doi.org/10.1117/12.2253328

KEYWORDS: Lithium, Capillaries, Oxygen, Optical coherence tomography, Imaging systems, In vivo imaging, Angiography, Visualization, Spatial resolution, Dynamical systems

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Proceedings Article | 19 April 2017 Presentation

Status of cerebral penetrating arterioles has important implication to stroke penumbra evaluation (Conference Presentation)

Yuandong Li, Ruikang Wang

Proceedings Volume 10050, 100500P (2017) https://doi.org/10.1117/12.2253313

KEYWORDS: Protactinium, Lithium, Arteries, Ischemia, Blood, Capillaries, Optical coherence tomography, Tissues, Injuries, Neurophotonics

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Proceedings Article | 8 March 2016 Paper

OCT-based in vivo tissue injury mapping

Utku Baran, Yuandong Li, Ruikang Wang

Proceedings Volume 9697, 969725 (2016) https://doi.org/10.1117/12.2214496

KEYWORDS: Tissue optics, Optical coherence tomography, Signal attenuation, In vivo imaging, Injuries, Image processing, Skin, Visualization, Image resolution, Blood

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SPIE Journal Paper | 12 June 2015 Open Access

Vasodynamics of pial and penetrating arterioles in relation to arteriolo-arteriolar anastomosis after focal stroke

Utku Baran, Yuandong Li, Ruikang Wang

NPh, Vol. 2, Issue 02, 025006, (June 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.2.025006

KEYWORDS: Blood, Blood circulation, Arteries, Lithium, Capillaries, 3D image processing, Neurophotonics, Cranial windows, Ischemia, Optical coherence tomography

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Proceedings Article | 2 March 2015 Paper

Optical microangiography reveals collateral blood perfusion dynamics in mouse cerebral cortex after focal stroke

Utku Baran, Yuandong Li, Ruikang Wang

Proceedings Volume 9312, 93121A (2015) https://doi.org/10.1117/12.2082311

KEYWORDS: Blood, Cerebral cortex, Cranial windows, Capillaries, Optical coherence tomography, 3D image processing, Neodymium, Doppler effect, Arteries, Visualization

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Proceedings Article | 26 February 2015 Paper

Microvascular changes during acne lesion initiation and scarring within human skin is revealed in vivo using optical microangiography

Utku Baran, Yuandong Li, Woo Choi, Ruikang Wang

Proceedings Volume 9303, 93030J (2015) https://doi.org/10.1117/12.2082717

KEYWORDS: Skin, In vivo imaging, Tissue optics, Optical coherence tomography, 3D image processing, Tissues, Imaging systems, Inflammation, Clinical trials, Image resolution

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SPIE Journal Paper | 23 October 2014 Open Access

Does optical microangiography provide accurate imaging of capillary vessels?: validation using multiphoton microscopy

Hequn Wang, Utku Baran, Yuandong Li, Wan Qin, Wenbo Wang, Haishan Zeng, Ruikang Wang

JBO, Vol. 19, Issue 10, 106011, (October 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.10.106011

KEYWORDS: Capillaries, Visualization, Tissues, Tissue optics, Multiphoton microscopy, Neuroimaging, Brain, In vivo imaging, Image resolution, Biomedical optics

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