Mr. Xiaozhi Cao Profile

Xiaozhi Cao

at Zhejiang Univ

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Proceedings Article | 9 September 2019 Paper

Highly efficient MRI through multi-shot echo planar imaging

Congyu Liao, Xiaozhi Cao, Jaejin Cho, Zijing Zhang, Kawin Setsompop, Berkin Bilgic

Proceedings Volume 11138, 1113818 (2019) https://doi.org/10.1117/12.2527183

KEYWORDS: Diffusion, Distortion, Magnetic resonance imaging, Signal to noise ratio, Computer programming, Data acquisition, Image resolution, Diffusion weighted imaging, Image quality standards, Data modeling

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Multi-shot echo planar imaging (msEPI) is a promising approach to achieve high in-plane resolution with high sampling efficiency and low T₂* blurring. However, due to the geometric distortion, shot-to-shot phase variations and potential subject motion, msEPI continues to be a challenge in MRI. In this work, we introduce acquisition and reconstruction strategies for robust, high-quality msEPI without phase navigators. We propose Blip Up-Down Acquisition (BUDA) using interleaved blip-up and -down phase encoding, and incorporate B₀ forward-modeling into Hankel structured low-rank model to enable distortion- and navigator-free msEPI. We improve the acquisition efficiency and reconstruction quality by incorporating simultaneous multi-slice acquisition and virtual-coil reconstruction into the BUDA technique. We further combine BUDA with the novel RF-encoded gSlider acquisition, dubbed “BUDA-gSlider”, to achieve rapid high isotropic resolution MRI. Deploying BUDA-gSlider with model-based reconstruction allows for distortion-free whole-brain 1mm isotropic T₂ mapping in ~1 minute. It also provides whole-brain 1mm isotropic diffusion imaging with high geometric fidelity and SNR efficiency. We finally incorporate sinusoidal “wave” gradients during the EPI readout to better use coil sensitivity encoding with controlled aliasing.

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