Mr. Weylan R. Thompson Profile

Weylan R. Thompson

at PhotoSound Technologies, Inc.

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Author

Publications (10)

Proceedings Article | 12 March 2024 Presentation + Paper

High-throughput photoacoustic tomography by integrated robotics and automation

Nathanael Marshall, Hans-Peter Brecht, Weylan Thompson, Dylan Lawrence, Vanessa Marshall, Samuel Toler, Stanislav Emelianov, Anthony Yu, Mark Anastasio, Umberto Villa, Joshua Maxwell, Sergey Ermilov

Proceedings Volume 12842, 128420I (2024) https://doi.org/10.1117/12.3005569

KEYWORDS: Imaging systems, Animals, Photoacoustic spectroscopy, Control systems, Spatial resolution, Animal model studies, Robotics, Acquisition tracking and pointing, Automation, Laser safety

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SPIE Journal Paper | 19 January 2024 Open Access

Spatiotemporal image reconstruction to enable high-frame-rate dynamic photoacoustic tomography with rotating-gantry volumetric imagers

Refik Mert Cam, Chao Wang, Weylan Thompson, Sergey A. Ermilov, Mark A. Anastasio, Umberto Villa

JBO, Vol. 29, Issue S1, S11516, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S1.S11516

KEYWORDS: Image restoration, Tomography, Photoacoustic tomography, Imaging systems, Transducers, Data acquisition, Biomedical optics, Matrices, Image processing, Video

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SignificanceDynamic photoacoustic computed tomography (PACT) is a valuable imaging technique for monitoring physiological processes. However, current dynamic PACT imaging techniques are often limited to two-dimensional spatial imaging. Although volumetric PACT imagers are commercially available, these systems typically employ a rotating measurement gantry in which the tomographic data are sequentially acquired as opposed to being acquired simultaneously at all views. Because the dynamic object varies during the data-acquisition process, the sequential data-acquisition process poses substantial challenges to image reconstruction associated with data incompleteness. The proposed image reconstruction method is highly significant in that it will address these challenges and enable volumetric dynamic PACT imaging with existing preclinical imagers.AimThe aim of this study is to develop a spatiotemporal image reconstruction (STIR) method for dynamic PACT that can be applied to commercially available volumetric PACT imagers that employ a sequential scanning strategy. The proposed reconstruction method aims to overcome the challenges caused by the limited number of tomographic measurements acquired per frame.ApproachA low-rank matrix estimation-based STIR (LRME-STIR) method is proposed to enable dynamic volumetric PACT. The LRME-STIR method leverages the spatiotemporal redundancies in the dynamic object to accurately reconstruct a four-dimensional (4D) spatiotemporal image.ResultsThe conducted numerical studies substantiate the LRME-STIR method’s efficacy in reconstructing 4D dynamic images from tomographic measurements acquired with a rotating measurement gantry. The experimental study demonstrates the method’s ability to faithfully recover the flow of a contrast agent with a frame rate of 10 frames per second, even when only a single tomographic measurement per frame is available.ConclusionsThe proposed LRME-STIR method offers a promising solution to the challenges faced by enabling 4D dynamic imaging using commercially available volumetric PACT imagers. By enabling accurate STIRs, this method has the potential to significantly advance preclinical research and facilitate the monitoring of critical physiological biomarkers.

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Proceedings Article | 7 April 2023 Presentation

Low-rank matrix estimation-based spatiotemporal image reconstruction from few tomographic measurements per frame for dynamic photoacoustic computed tomography

Refik Mert Cam, Chao Wang, Weylan Thompson, Sergey Ermilov, Mark Anastasio, Umberto Villa

Proceedings Volume 12463, 124630R (2023) https://doi.org/10.1117/12.2654199

KEYWORDS: Photoacoustic tomography, Tomography, Image restoration, Image analysis, Tissue optics, Biomedical optics, Tissues, Data acquisition, Biological research, Tumors

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Proceedings Article | 9 March 2023 Presentation + Paper

Dynamic image reconstruction to monitor tumor vascular perfusion in small animals using 3D photoacoustic computed-tomography imagers with rotating gantries

Refik Mert Cam, Chao Wang, Seonyeong Park, Weylan Thompson, Sergey Ermilov, Mark Anastasio, Umberto Villa

Proceedings Volume 12379, 123790F (2023) https://doi.org/10.1117/12.2647663

KEYWORDS: Photoacoustic tomography, Tumors, Imaging systems, Acoustics, Matrices, Tomography, 3D image reconstruction, Preclinical imaging, Iterative methods, Inverse imaging problems, Small animal whole body imaging

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SPIE Journal Paper | 7 March 2023 Open Access

Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies

Weylan R. Thompson, Hans-Peter F. Brecht, Vassili Ivanov, Anthony M. Yu, Diego S. Dumani, Dylan J. Lawrence, Stanislav Y. Emelianov, Sergey A. Ermilov

JBO, Vol. 28, Issue 03, 036001, (March 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.3.036001

KEYWORDS: Spatial resolution, Imaging systems, Photoacoustic spectroscopy, In vivo imaging, Acquisition tracking and pointing, Fluorescence imaging, Vacuum chambers, Biological imaging, Cameras, Reconstruction algorithms

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Proceedings Article | 3 March 2022 Presentation + Paper

A combined ultrasound and photoacoustic imaging platform for clinical research applications

Weylan Thompson, Hans-Peter Brecht, Sergey Ermilov, Vassili Ivanov

Proceedings Volume 11960, 119600K (2022) https://doi.org/10.1117/12.2610099

KEYWORDS: Spatial resolution, Imaging systems, Ultrasonography, Photoacoustic imaging, In vivo imaging, Signal detection, Video, Functional imaging, Doppler effect, Data acquisition

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Proceedings Article | 6 March 2021 Presentation

Dynamic reconstruction of three-dimensional photoacoustic tomography from few projections

Chao Wang, Umberto Villa, Weylan Thompson, Seonyeong Park, Sergey Ermilov, Mark Anastasio

Proceedings Volume 11642, 116421A (2021) https://doi.org/10.1117/12.2585344

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, 3D metrology, Reconstruction algorithms, 3D image reconstruction, Tomography, Tissues, Tissue optics, Temporal resolution, Numerical simulations

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Proceedings Article | 17 February 2020 Presentation + Paper

A preclinical small animal imaging platform combining multi-angle photoacoustic and fluorescence projections into co-registered 3D maps

Weylan Thompson, Anthony Yu, Diego Dumani, Jason Cook, Mark Anastasio, Stanislav Emelianov, Sergey Ermilov

Proceedings Volume 11240, 112400L (2020) https://doi.org/10.1117/12.2549088

KEYWORDS: Photoacoustic imaging, Fluorescence tomography, Contrast sensitivity, Photoacoustic tomography, Optical imaging, In vivo imaging

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Proceedings Article | 17 February 2020 Paper

Massive parallel ultrasound and photoacoustic PC-based system

Weylan Thompson, Hans Peter Brecht, Sergey Ermilov, Vassili Ivanov

Proceedings Volume 11240, 112404H (2020) https://doi.org/10.1117/12.2547377

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Interfaces, Field programmable gate arrays, Data acquisition, Connectors, Visualization, Phased arrays

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Proceedings Article | 19 March 2019 Paper

Preclinical small animal imaging platform providing co-registered 3D maps of photoacoustic response and fluorescence

Diego Dumani, Anthony Yu, Weylan Thompson, Hans-Peter Brecht, Vassili Ivanov, Mark Anastasio, Jason Cook, Sergey Ermilov, Stanislav Emelianov

Proceedings Volume 10878, 108784Y (2019) https://doi.org/10.1117/12.2514489

KEYWORDS: Skin, Luminescence, Photoacoustic spectroscopy, Tissues, 3D image processing, Animal model studies, Preclinical imaging, Spatial resolution, In vivo imaging, Acquisition tracking and pointing

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Showing 5 of 10 publications

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