Dr. Wei-Chung Cheng Profile

Dr. Wei-Chung Cheng

General Engineer at US Food and Drug Administration

SPIE Involvement:

Conference Program Committee | Author

Proceedings Article | 15 February 2021 Presentation + Paper

Spatiotemporal characteristics of medical extended-reality systems

Andrea Kim, Wei-Chung Cheng, Ryan Beams, Aldo Badano

Proceedings Volume 11599, 1159906 (2021) https://doi.org/10.1117/12.2580736

KEYWORDS: Head-mounted displays, Sensors, Medical imaging, Augmented reality, Visualization, Ultrasonography, Sensor technology, Radiography, Medical devices, Magnetism

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Proceedings Article | 15 February 2021 Presentation + Paper

Colorimetrical evaluation of color normalization methods for H&E-stained images

Jocelyn Liu, Samuel Lam, Paul Lemaillet, Wei-Chung Cheng

Proceedings Volume 11603, 116030U (2021) https://doi.org/10.1117/12.2582281

KEYWORDS: Tissues, Visualization, Transmittance, Scanners, Principal component analysis, Pathology, Image processing, Diagnostics

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Proceedings Article | 16 March 2020 Paper

Characterization of color normalization methods in digital pathology whole slide images

Dorsa Ziaei, Weizhe Li, Samuel Lam, Wei-Chung Cheng, Weijie Chen

Proceedings Volume 11320, 1132017 (2020) https://doi.org/10.1117/12.2550585

KEYWORDS: Scanners, Color difference, Pathology, Artificial intelligence, Algorithm development

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The color rendering of whole-slide images (WSIs) depends on factors involving the sample, such as tissue type, preparation methods, staining type and staining protocol, as well as equipment, such as the WSI scanner, WSI viewer, and WSI display. Variations in any of these steps may change the color rendering and therefore affect the performance of pathologists in the interpretation of WSIs and the robustness of artificial intelligence algorithms. In the literature, color normalization techniques have been proposed to reduce the color variations. The purpose of this work is to develop an objective approach to characterizing color normalization methods used in digital pathology. We employed color normalization methods to normalize the color rendered by a WSI scanner and then compared the normalized color with the actual scan by that scanner. The normalization errors were evaluated on the pixel level using the CIE color difference ΔE metric that have been shown to correlate with visually perceived differences in human vision. A selected set of 310 patch images of breast tissues scanned by two scanners from the ICPR 2014 MITOS & ATYPIA contest was used. Images from one scanner were color normalized to match the color rendering of the other scanner. Four color normalization methods were compared – Macenko, Reinhard, Vahadane, and StainGAN. Experimental results show that average color differences between two scanners in terms of ΔE were reduced from 16.2 before normalization to the range of [13.7,16.9] after normalization for the Macenko, Reinhard, Vahadane methods, and to 8.3 for the StainGAN method. Apparently the StainGAN method is significantly superior to the other three methods in terms of the ΔE metric. As such, we demonstrated a quantitative method for objectively evaluating color normalization techniques. Future work is needed to explore the relationship of the color fidelity measure and the impact of color normalization on pathologist and AI performance in clinical tasks.

Proceedings Article | 1 March 2017 Paper

Evaluating color performance of whole-slide imaging devices by multispectral-imaging of biological tissues

Firdous Saleheen, Aldo Badano, Wei-Chung Cheng

Proceedings Volume 10140, 101400R (2017) https://doi.org/10.1117/12.2254997

KEYWORDS: Pathology, Kidney, Human vision and color perception, Color reproduction, Tissues, Imaging devices, Multispectral imaging, Color difference, Transmittance, Colon, Skin, Optical microscopes, Light sources

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SPIE Journal Paper | 9 May 2016 Open Access

Development of the local magnification method for quantitative evaluation of endoscope geometric distortion

Quanzeng Wang, Wei-Chung Cheng, Nitin Suresh, Hong Hua

JBO, Vol. 21, Issue 05, 056003, (May 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.5.056003

KEYWORDS: Distortion, Endoscopes, Lawrencium, Standards development, Endoscopy, Image sensors, Data centers, Image processing, Monochromatic aberrations, Image analysis

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Proceedings Article | 18 March 2015 Paper

Comparison of methods for quantitative evaluation of endoscopic distortion

Quanzeng Wang, Kurt Castro, Viraj Desai, Wei-Chung Cheng, Joshua Pfefer

Proceedings Volume 9412, 94123A (2015) https://doi.org/10.1117/12.2082077

KEYWORDS: Distortion, Endoscopes, Endoscopy, Standards development, Ruthenium, Image analysis, Image quality standards, Optical proximity correction, Image quality, Medical imaging

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SPIE Journal Paper | 12 November 2014 Open Access

Evaluation environment for digital and analog pathology: a platform for validation studies

Brandon Gallas, Marios Gavrielides, Catherine Conway, Adam Ivansky, Tyler Keay, Wei-Chung Cheng, Jason Hipp, Stephen Hewitt

JMI, Vol. 1, Issue 03, 037501, (November 2014) https://doi.org/10.1117/12.10.1117/1.JMI.1.3.037501

KEYWORDS: Microscopes, Image registration, Cameras, Pathology, Analog electronics, Glasses, Reticles, MATLAB, Tissues, Imaging systems

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Proceedings Article | 11 March 2014 Paper

eeDAP: an evaluation environment for digital and analog pathology

Brandon Gallas, Wei-Chung Cheng, Marios Gavrielides, Adam Ivansky, Tyler Keay, Adam Wunderlich, Jason Hipp, Stephen Hewitt

Proceedings Volume 9037, 903709 (2014) https://doi.org/10.1117/12.2044443

KEYWORDS: Microscopes, Cameras, Image registration, Pathology, Reticles, Glasses, Analog electronics, Tissues, MATLAB, Transmittance

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Proceedings Article | 31 December 2013 Paper

Towards standardized assessment of endoscope optical performance: geometric distortion

Quanzeng Wang, Viraj Desai, Ying Ngo, Wei-Chung Cheng, Joshua Pfefer

Proceedings Volume 9042, 904205 (2013) https://doi.org/10.1117/12.2044103

KEYWORDS: Distortion, Endoscopes, Endoscopy, Standards development, Image quality standards, Geometrical optics, Optical proximity correction, MATLAB, Image analysis, Image quality

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Proceedings Article | 29 March 2013 Paper

Assessing color reproducibility of whole-slide imaging scanners

Wei-Chung Cheng, Tyler Keay, Neil O'Flaherty, Joel Wang, Adam Ivansky, Marios Gavrielides, Brandon Gallas, Aldo Badano

Proceedings Volume 8676, 86760O (2013) https://doi.org/10.1117/12.2007215

KEYWORDS: Scanners, Color management, Transmittance, Color difference, Light sources, Imaging systems, Digital imaging, Photography, Glasses, Field programmable gate arrays

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Proceedings Article | 7 March 2012 Paper

Evaluating color calibration kits with virtual display

Wei-Chung Cheng, Hugo Caceres, Aldo Badano

Proceedings Volume 8292, 82920A (2012) https://doi.org/10.1117/12.909660

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Proceedings Article | 7 March 2012 Paper

Impact of solid-state lighting on observer performance of color discrimination

Wei-Chung Cheng, Widad Tannous, Aldo Badano

Proceedings Volume 8318, 83181T (2012) https://doi.org/10.1117/12.912436

KEYWORDS: Light sources, Solid state lighting, Visualization, Light emitting diodes, Tungsten, Lamps, Halogens, Photography, Light sources and illumination, Color vision

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Proceedings Article | 3 March 2010 Paper

A gaze-contingent high-dynamic range display for medical imaging applications

Wei-Chung Cheng, Aldo Badano

Proceedings Volume 7627, 76270A (2010) https://doi.org/10.1117/12.845782

KEYWORDS: Image processing, LCDs, Medical imaging, High dynamic range imaging, Cameras, Eye, Infrared cameras, Medical imaging applications, Visual system, Infrared imaging

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Showing 5 of 13 publications

Conference Committee Involvement (8)