The relentless rise of Multidrug-Resistant (MDR) bacteria significantly challenges global health, undermining the effectiveness of traditional antibiotics and demanding prompt development of new antimicrobial strategies. This study investigates the antimicrobial properties of Gamma-Aminobutyric Acid (GABA) silver nanoparticles (GABAAgNPs). GABAAgNPs were synthesized via photoreduction and subsequently characterized using UV-Vis spectroscopy, Transmission Electron Microscopy (TEM), and Zeta potential analysis. Their antimicrobial potential was assessed through a Minimum Inhibitory Concentration (MIC) assay. The photodynamic effect was studied under irradiation at the following wavelengths: 460 +/- 10 nm (2 min), 590 nm +/- 10 nm (2 min), and 660 nm +/- 10 nm for 2, 5, and 10 minutes. Our results demonstrated that GABAAgNPs induced porphyrin formation in E. coli, leading to microbial inhibition, further enhanced through the photodynamic effect. Thus, GABAAgNPs display dual functionality: directly targeting microbes while concurrently acting as photosensitizers in antimicrobial photodynamic inactivation (aPDI).
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.