In the paper the mathematical model of kinetics of interaction of the injected compound with biological liquid flow has been described for different means of cells concentrations connected on packed cell volume. It is considered that biological liquid contains a three phases such as water, peptides and cells. At the time, the injected compound can interact with peptides and cells which are "trap" for him. The obtained distribution of the compound connects on changes of its fluorescence spectra. It is shown that fluorescence intensivity change is different at 560, 580 and 590 nm. The curves do not have monotonic nature. There is a sharp curves decline in the first few seconds, next, it are increasing. Curves inflection time slightly depends on the cells concentration and is 7-9 seconds. At the time stationary concentration significantly depends on this parameter in contrast to blood viscosity. As long s cells concentration is primarily mean of the packed cell volume, the model can be important for pharmacokinetics and preparations delivery. It can be also used for fluorescent biomedical diagnostics of cancer tumour.
This work describes availability of immobilization of monomers and dimers of erythrosine into collagenase molecules. By means of the spectral investigations it was obtained that emission of the dye dimers dissolved in collagenase solution is. Erythrosine dimers don't fluoresce in water and buffer solutions; however its fluorescence can be seen if complexes of monomer-ferment and dimers-ferment were formed.
Delayed fluorescence kinetics of exogenous fluorophores in tumor and normal mice mammary tissue cells
was researched. Delayed fluorescence kinetics of fluorophores in two types of cells was researched on in its
specific features and regularities. The investigation results are discussed in the context of early fluorescent
diagnostics method of tissue pathological states.
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