A novel technique based on optical coherence tomography (OCT) for noninvasive glucose monitoring is proposed. The feasibility of the proposed technique is demonstrated by detecting the glucose concentration of aqueous solution ranging from 0-4000 mg/dL with 0.02% lipofundin. The practical applicability of the proposed technique is demonstrated by detecting the glucose concentration of the human fingertip tissue based on the oral glucose tolerance test (OGTT).
A method is proposed for determining the glucose concentration on the human fingertip by extracting two optical parameters, namely the optical rotation angle and the depolarization index, using a Mueller optical coherence tomography technique and a genetic algorithm. The feasibility of the proposed method is demonstrated by measuring the optical rotation angle and depolarization index of aqueous glucose solutions with low and high scattering, respectively. It is shown that for both solutions, the optical rotation angle and depolarization index vary approximately linearly with the glucose concentration. As a result, the ability of the proposed method to obtain the glucose concentration by means of just two optical parameters is confirmed. The practical applicability of the proposed technique is demonstrated by measuring the optical rotation angle and depolarization index on the human fingertip of healthy volunteers under various glucose conditions.
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