Visual stimulation-induced increase in the metabolic activity of retinal neurons leads to temporary vasodilation of retinal blood vessels and an increase in the retinal blood flow, which is often referred to as functional hyperaemia. Neurodegenerative retinal diseases such as glaucoma, age-related macular degeneration, and diabetic retinopathy have been known to cause progressive damage to the retinal morphology, blood perfusion and retinal blood flow, and eventually lead to blindness. In this study, we utilize a combined OCT+ERG system to investigate functional hyperemia in the human retina.
Visually-evoked retinal neuronal simulation-induced transient vasodilation of retinal blood vessels is referred to as neurovascular coupling. Both systemic diseases such as Diabetes and high blood pressure, as well as potentially blinding retinal diseases such as Glaucoma have been shown to damage the elasticity of the blood vessels’ walls. In this study, a research-grade, high-resolution OCT system is combined with a commercial electroretinography (ERG) system to investigate flicker-stimulus-induced transient vasodilation in retinal blood vessels around the Optic Nerve Head and study neurovascular coupling in the human retina.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.