Unspecified Tianyi Wang Profile

Tianyi Wang

Optical Design Engineer

SPIE Involvement:

Author

Area of Expertise:

Thermal imaging , multi-photon luminescence microscopy (TPLM) , modeling of light and heat transfer in tissue , optical coherence tomography (OCT) , nanoparticle , medical image processing

Currently a post-doctoral research associate working on cardiovascular disease detection in the Department of Biomedical Engineering at the University of Texas at Austin. Research area includes medical imaging system design, modeling and image processing, specifically in thermal imaging, optical coherence tomography, fluorescence imaging, modeling of light and heat transfer in tissue and medical image processing.

Project Experience:
6/2012-Present
Design of a Combined Fiber-based Two-photon Luminescence (TPL) and Optical Coherence Tomography (OCT) System and an Intravascular Imaging Catheter for Macrophage Detection in Atherosclerotic Plaques. A portable fiber-based TPL-OCT system with high power is designed and currently under instrumentation. Ray trace simulation is performed using Zemax to test macrophage imaging capability of the catheter compared to an ex vivo TPL microscope and to optimize the GRIN lens design in the catheter.

6/2009-5/2012
Macrophage and Lipid Detection in Atherosclerotic Plaques Using Gold Nanoparticles and Three Imaging Modalities: Optical Coherence Tomography (OCT), Photothermal Wave (PTW) Imaging and Two-photon Luminescence Microscopy (TPLM). Developed two hybrid imaging systems, PTW-OCT and TPLM-OCT, for atherosclerotic plaque detection. Specifically, PTW-OCT was utilized to visualize plaque-based macrophages and lipid deposits at multiple depths; TPLM-OCT was used to characterize the 3-D distribution of macrophages with respect to plaque surface profile at a higher resolution. The background subtraction algorithm was developed to enhance PTW images.

Awards:
3/2011 Graduate School Continuing Fellowship, University of Texas at Austin
2/2011 Best Student Paper Award, The American Society for Laser Medicine and Surgery (ASLMS)
1/2009 Research Excellence Award, The International Society for Optical Engineering (SPIE)
6/2005 Outstanding Graduate, Wuhan University

SPIE Journal Paper | 5 November 2015 Open Access

Differences in forward angular light scattering distributions between M1 and M2 macrophages

David Halaney, Aydin Zahedivash, Jennifer Phipps, Tianyi Wang, Jordan Dwelle, Claude Jourdan Le Saux, Reto Asmis, Thomas Milner, Marc Feldman

JBO, Vol. 20, Issue 11, 115002, (November 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.11.115002

KEYWORDS: Light scattering, Scattering, CMOS sensors, Control systems, Polarization, Tissues, NOx, Refractive index, Cancer, In vitro testing

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SPIE Journal Paper | 29 December 2014 Open Access

Intravascular optical coherence tomography light scattering artifacts: merry-go-rounding, blooming, and ghost struts

J. Jacob Mancuso, David Halaney, Sahar Elahi, Derek Ho, Tianyi Wang, Yongjian Ouyang, Jouke Dijkstra, Thomas Milner, Marc Feldman

JBO, Vol. 19, Issue 12, 126017, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.12.126017

KEYWORDS: Blood, Optical coherence tomography, Light scattering, Scattering, 3D image reconstruction, 3D image processing, Contamination, Image acquisition, Statistical analysis, In vitro testing

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SPIE Journal Paper | 27 March 2012 Open Access

Dual-wavelength multifrequency photothermal wave imaging combined with optical coherence tomography for macrophage and lipid detection in atherosclerotic plaques using gold nanoparticles

Tianyi Wang, J. Jacob Mancuso, Veronika Sapozhnikova, Jordan Dwelle, Li Ma, Brian Willsey, S. Shams Kazmi, Jinze Qiu, Xiankai Li, Reto Asmis, Keith Johnston, Marc Feldman, Thomas Milner

JBO, Vol. 17, Issue 03, 036009, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.3.036009

KEYWORDS: Optical coherence tomography, Image segmentation, Modulation, Nanoparticles, Luminescence, Optical imaging, Microscopy, Laser irradiation, Absorption, Gold

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SPIE Journal Paper | 7 March 2012 Open Access

Use of near-infrared luminescent gold nanoclusters for detection of macrophages

Veronika Sapozhnikova, Brian Willsey, Li Leo Ma, Keith Johnston, Reto Asmis, Tianyi Wang, James Jenkins, Jacob Mancuso, Roman Kuranov, Thomas Milner, Marc Feldman

JBO, Vol. 17, Issue 02, 026006, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.026006

KEYWORDS: Nanoparticles, Gold, Luminescence, Iron, Oxides, Coating, Confocal microscopy, Particles, Transmission electron microscopy, Molecules

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Proceedings Article | 30 January 2012 Paper

High-speed polarization sensitive optical coherence tomography for retinal diagnostics

Biwei Yin, Bingqing Wang, Kalyanramu Vemishetty, Jim Nagle, Shuang Liu, Tianyi Wang, Henry Rylander, Thomas Milner

Proceedings Volume 8213, 82132W (2012) https://doi.org/10.1117/12.911447

KEYWORDS: Polarization, Birefringence, Optical coherence tomography, Imaging systems, Eye, Field programmable gate arrays, Tissue optics, Diagnostics, Nerve, Computing systems

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SPIE Journal Paper | 1 July 2011 Open Access

Changes in morphology and optical properties of sclera and choroidal layers due to hyperosmotic agent

Raiyan Zaman, Brandon Nichols, Henry Rylander, Tianyi Wang, James Tunnell, Ashley Welch, Narasimhan Rajaram

JBO, Vol. 16, Issue 07, 077008, (July 2011) https://doi.org/10.1117/12.10.1117/1.3599985

KEYWORDS: Sclera, Blood vessels, Optical properties, Blood, Absorption, Scattering, Eye, Tissue optics, Tissues, Phase modulation

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Proceedings Article | 18 February 2011 Paper

Fluorescence imaging of macrophages in atherosclerotic plaques using plasmonic gold nanorose

Tianyi Wang, Veronika Sapozhnikova, J. Jacob Mancuso, Brian Willsey, Jinze Qiu, Li Ma, Xiankai Li, Keith Johnston, Marc Feldman, Thomas Milner

Proceedings Volume 7883, 788331 (2011) https://doi.org/10.1117/12.874076

KEYWORDS: Luminescence, Tissues, Particle filters, Confocal microscopy, Gold, Plasmonics, 3D image reconstruction, Signal detection, Modulation, Tissue optics

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SPIE Journal Paper | 1 March 2010 Open Access

Femtosecond laser lithotripsy: feasibility and ablation mechanism

Jinze Qiu, Joel Teichman, Tianyi Wang, Joseph Neev, Randolph Glickman, Kin Foong Chan, Thomas Milner

JBO, Vol. 15, Issue 02, 028001, (March 2010) https://doi.org/10.1117/12.10.1117/1.3368998

KEYWORDS: Laser ablation, Femtosecond phenomena, Calculi, Plasma, Calculus, Laser lithotripsy, Pulsed laser operation, Laser therapeutics, Ferroelectric polymers, Photography

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Proceedings Article | 26 February 2010 Paper

Nanorose and lipid detection in atherosclerotic plaque using dual-wavelength photothermal wave imaging

Tianyi Wang, Jinze Qiu, Li Leo Ma, Xiankai Li, Jingjing Sun, Seungyup Ryoo, Keith Johnston, Marc Feldman, Thomas Milner

Proceedings Volume 7562, 75620S (2010) https://doi.org/10.1117/12.840744

KEYWORDS: Modulation, Infrared cameras, Arteries, Tissues, Laser irradiation, Natural surfaces, Infrared imaging, Image segmentation, Cameras, Laser tissue interaction

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Proceedings Article | 7 March 2009 Paper

Near infrared femtosecond laser ablation of urinary calculi in water

Jinze Qiu, Joel Teichman, Roman Kuranov, Austin McElroy, Tianyi Wang, Amit Paranjape, Thomas Milner

Proceedings Volume 7203, 720309 (2009) https://doi.org/10.1117/12.809196

KEYWORDS: Calculi, Laser ablation, Femtosecond phenomena, Optical coherence tomography, Objectives, Pulsed laser operation, Near infrared, Laser therapeutics, Absorption, Optical fibers

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Proceedings Article | 12 February 2009 Paper

Melanoma thickness measurement in two-layer tissue phantoms using pulsed photothermal radiometry (PPTR)

Tianyi Wang, Jinze Qiu, Amit Paranjape, Thomas Milner

Proceedings Volume 7175, 71750L (2009) https://doi.org/10.1117/12.807931

KEYWORDS: Tissues, Melanoma, Monte Carlo methods, Laser tissue interaction, 3D modeling, Temperature metrology, Radiometry, Tissue optics, Pulsed laser operation, Absorption

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Proceedings Article | 12 February 2009 Paper

Changes in morphology and optical properties of sclera due to hyperosmotic agent

Raiyan Zaman, Henry Rylander, Narasimhan Rajaram, Tianyi Wang, Nitin Asokan, James Tunnell, Ashley Welch

Proceedings Volume 7175, 71750D (2009) https://doi.org/10.1117/12.809701

KEYWORDS: Sclera, Optical properties, Scattering, Absorption, Blood vessels, Eye, Oxygen, Blood, Light scattering, Eye models

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The primary and the secondary goals of this study were to investigate the change in morphology and optical properties of sclera due to a hyperosmotic agent i.e. 100% anhydrous glycerol. We performed our experiments in vivo on the sclera of 8 rabbits and 3 miniature pigs. All the animals were under anesthetic for the entire experiment according to an approved protocol. The position of the eye was stabilized with a suture placed in the limbus. Glycerol was delivered to sclera in 2 methods (i) injection (using a hypodermic needle 27G ½), (ii) direct application after 0.3 cm incision at conjunctiva. A camera attached to a slit lamp was used to capture the morphological changes of the sclera. For the secondary goal we used a diffuse optical spectroscopy (DOS) system with a linear fiber arrangement to measure reflectance from the sclera before and after application of glycerol. The probe source-detector separation was set to 370 μm for optimal penetration depth. We fit the measured diffuse reflectance to a Lookup Table (LUT)-based inverse model specific to our probe geometry to determine the scattering and absorption properties of the sclera. This method estimated the size and density of scatterers, absorbers-blood volume fraction, melanin concentration, oxygen saturation, and blood vessel size. The results illustrated that the initial clearing of sclera started 3 minutes after injecting glycerol to sclera. The sclera became completely transparent at 8 minutes and stayed clear for 10-15 minutes. During this time the choroid layer was visible through sclera. The clear sclera became less transparent over next 11 minutes and became completely opaque once we applied 0.9% saline to hydrate the sclera. These dehydration and hydration cycles were repeated 4 times for each eye and the results were consistent for all animal models. When glycerol was applied directly to sclera after the incision at the conjunctiva, the sclera became transparent instantaneously. For the secondary goal, the changes in optical properties of sclera were monitored during the dehydration and hydration cycles. The reduced scattering coefficient decreased when glycerol was injected and it further reduced with direct application. The scattering increased after re-hydration. We also measured the blood volume fraction, melanin concentration, oxygen saturation, and blood vessels diameter to calculate absorption coefficient with the DOS system. This study provided a novel way to identify morphological changes of sclera in addition to measuring changes in optical properties due to hyper osmotic agent. The changes in optical properties were consistent with the morphological changes in sclera during the dehydration and hydration cycles.

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