Tunable laser sources with sweep-rates higher than 1MHz recently became commercially available. Today’s commercial ophthalmic OCT systems use sweep-rates in the 100-200kHz regime. These much faster laser sources can be used to either significantly reduce the imaging time or significantly increase the field of view (FOV). In this study we investigate the clinical value of OCT with MHz-rate swept source lasers. We implemented a versatile ophthalmic OCT system using a Frequency-Domain-Mode-Locked (FDML) laser with a sweep-rate of 1.7MHz, to address a variety of ophthalmic OCT imaging applications, exhibiting large imaging depth for wide field retinal OCT and OCT angiography (OCTA) with a field of view of up to 90 degrees, as well as for anterior segment imaging, and microscopic OCTA of the choriocapillaris with repetition rates of more than 1kHz.
Side lobe artifacts on point spread functions can be traced back to (1) fringe visibility variation across the spectrum, (2) errors in sampling instances, and (3) window functions. We demonstrate signal processing methods for correcting for all three of these issues. These methods require a system calibration step. If the systems slowly age, the recalibration step could be performed in the field with a fixtured target.
The choriocappilaris layer is considered to be one of the first retinal layers affected in age related macular degeneration and other retinal diseases [1]. Imaging this fine vascular layer below the retinal pigment epithelium (RPE) with optical coherence tomography angiography (OCTA) has been very challenging due to the high scattering and absorption of the RPE. In OCTA higher inter B-scan times increase the sensitivity for slow motion and hence improve the contrast of fine vessels. However, it was demonstrated that for the choriocappilaris the opposite is the case [2]. Novel swept source laser technology enables acquiring images at A-scan-rates of 1.7 million A-scans per second, which is approx. 17 times faster than the fastest commercially available OCT devices [3, 4]. OCTA images of the human macula with different inter B-scan times were acquired and compared. The same prototype system was also used to acquire single shot wide-field OCTA images with up to 60 degree field of view.
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