Dr. Philipp Johannes Thurner Profile

Dr. Philipp Johannes Thurner

at Technische Univ Wien

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Publications (4)

Proceedings Article | 13 March 2006 Paper

Functional microimaging: an integrated approach for advanced bone biomechanics and failure analysis

Romain Voide, G. van Lenthe, Philipp Schneider, Philipp Thurner, Peter Wyss, Urs Sennhauser, Marco Stampanoni, Martin Stauber, Jess Snedeker, Ralph Müller

Proceedings Volume 6143, 61430X (2006) https://doi.org/10.1117/12.650485

KEYWORDS: Bone, Visualization, Head, Tomography, Image resolution, Nondestructive evaluation, 3D image processing, Failure analysis, High speed cameras, Neck

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Biomechanical testing is the gold standard to determine bone competence, and has been used extensively. Direct mechanical testing provides detailed information on overall bone mechanical and material properties, but fails in revealing local properties such as local deformations and strains or quantification of fracture progression. Therefore, we incorporated several imaging methods in our mechanical setups in order to get a better insight into bone deformation and failure characteristics. Our aim was to develop an integrative approach for hierarchical investigation of bone, working at different scales of resolution ranging from the whole bone to its ultrastructure. At a macroscopic level, we used high-resolution and high-speed cameras which drastically increased the amount of information obtained from a biomechanical bone test. The new image data proved especially important when dealing with very small bones such as the murine femur. Here the feedback of the camera in the process of aligning and positioning the samples is indispensable for reproducibility. In addition, global failure behavior and fracture initiation can now be visualized with high temporal resolution. At a microscopic level, bone microstructure, i.e. trabecular architecture and cortical porosity, are known to influence bone strength and failure mechanisms significantly. For this reason, we developed an image-guided failure assessment technique, also referred to as functional microimaging, allowing direct time-lapsed 3D visualization and computation of local displacements and strains for better quantification of fracture initiation and progression at the microscopic level. While the resolution of typical desktop micro-computed tomography is around a few micrometers, highly brilliant X-rays from synchrotron radiation permit to explore the nanometer world. This allowed, for the first time, to uncover fully nondestructively the 3D ultrastructure of bone including vascular and cellular structures and to investigate their role in development of bone microcracks in an unprecedented resolution. We conclude that functional microimaging, i.e. the combination of biomechanical testing with non-destructive 3D imaging and visualization are extremely valuable in studying bone failure mechanisms. Functional investigation of microcrack initiation and propagation will lead to a better understanding of the relative contribution of bone mass and bone quality to bone competence.

Proceedings Article | 14 April 2005 Paper

Novel techniques for high-resolution functional imaging of trabecular bone

Philipp Thurner, Ralph Muller, Johannes Kindt, Georg Schitter, Georg Fantner, Peter Wyss, Urs Sennhauser, Paul Hansma

Proceedings Volume 5746, (2005) https://doi.org/10.1117/12.595799

KEYWORDS: Bone, Atomic force microscopy, Tomography, Failure analysis, Collagen, Tissues, Synchrotron radiation, Spatial resolution, 3D image processing, Functional imaging

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Proceedings Article | 26 October 2004 Paper

Functional micro-imaging of soft and hard tissue using synchrotron light

Philipp Thurner, Peter Wyss, Romain Voide, Martin Stauber, Bert Muller, Marco Stampanoni, Jeffrey Hubbell, Ralph Muller, Urs Sennhauser

Proceedings Volume 5535, (2004) https://doi.org/10.1117/12.559515

KEYWORDS: Bone, Tomography, Tissues, Scanning electron microscopy, 3D image processing, 3D visualizations, Gold, Synchrotron radiation, Failure analysis, Positron emission tomography

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Proceedings Article | 7 January 2002 Paper

Nondestructive three-dimensional evaluation of biocompatible materials by microtomography using synchrotron radiation

Bert Muller, Philipp Thurner, Felix Beckmann, Timm Weitkamp, Christoph Rau, Ricardo Bernhardt, Erdal Karamuk, Ludwig Eckert, J. Brandt, Stefan Buchloh, Erich Wintermantel, Dieter Scharnweber, Hartmut Worch

Proceedings Volume 4503, (2002) https://doi.org/10.1117/12.452843

KEYWORDS: Bone, Tissues, Spatial resolution, Optical spheres, Polymers, Titanium, Modulation transfer functions, Human-machine interfaces, Synchrotron radiation, X-rays

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