Dr. Olaf Minet Profile

Dr. Olaf Minet

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Publications (32)

Proceedings Article | 9 April 2020 Paper

Monte Carlo simulation of signals in digital diaphanoscopy of the maxillary sinuses

E. Bryanskaya, R. Yu. Gneushev, I. Makovik, V. Dremin, A. Bukin, O. Bibikova, B. Shuraev, O. Minet, U. Zabarylo, A. Dunaev, V. Artyushenko

Proceedings Volume 11457, 114571K (2020) https://doi.org/10.1117/12.2564314

KEYWORDS: Monte Carlo methods, Tissues, Pathology, Tissue optics, Diagnostics, Tumors, Optical properties, Scattering, Bone, Sensors

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Proceedings Article | 2 April 2020 Presentation

Simulation of digital diaphanoscopy signal changes in an improved cross-sectional model (Conference Presentation)

Ekaterina Bryanskaya, Roman Gneushev, Irina Makovik, Viktor Dremin, Artem Bukin, Olga Bibikova, Boris Shuraev, Olaf Minet, Urszula Zabarylo, Andrey Dunaev, Viacheslav Artyushenko

Proceedings Volume 11363, 113631T (2020) https://doi.org/10.1117/12.2555150

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The digital diaphanoscopy method seems promising for solving one of the urgent problems of modern otolaryngology, which is associated with providing accurate, painless and timely diagnosis of pathologies of the maxillary sinuses. Optical properties of the study area and their changes for different anatomical and gender features and pathologies presence determine the results of digital diaphanoscopy. Adjusting the parameters of the probing and measuring parts of digital diaphanoscopy devices taking into account these factors is important task to obtain similar light scattering patterns for different patients and the possibility of their subsequent comparison. This paper presents the improved numerical model of the maxillary sinuses. The developed model considered the maxillary sinuses sizes, their location and asymmetry, various thicknesses of bone and soft tissues, size and localization of pathology (cystic fluid and tumor). The cross-sectional face model was more detailed and considered the curvature of the face. Simulation was carried out at various positioning of radiation source relative to the study area and detector. Additionally, the various rotation angles of the study area with radiation source relative to the detector were considered. The attenuation of probe radiation intensity at the detector was estimated using the Monte Carlo method in the TracePro (Lambda Software) for visible and near-IR wavelengths at the different intensity values. The correlations between model signal and anatomical features of the study area, and the changes of the study area position were identified. It was established that registration of light scattering patterns at different position is important parameter for more accurate evaluation of the maxillary sinuses state and the localization of pathologies. The threshold values of the probe radiation intensity and the optimal study positions, which provide the optimal signal-to-noise ratio of the detectable signals, were identify.

Proceedings Article | 22 July 2019 Paper

Clinical spectroscopy for biotissues and bioliquids

Olga Bibikova, Anastasya Melenteva, Valeria Belikova, Urszula Zabarylo, Thaddäus Hocotz, Iskander Usenov, Elena Feliksberger, Tatiana Sakharova, Georgy Danielyan, Olaf Minet, Viacheslav Artyushenko

Proceedings Volume 11079, 110790I (2019) https://doi.org/10.1117/12.2526586

KEYWORDS: Spectroscopy, Tissue optics, Cancer, Diagnostics, Biopsy, Kidney, Luminescence, Fluorescence spectroscopy, Tissues, Fiber optics

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Proceedings Article | 19 July 2019 Paper

Diagnosis of inflammatory diseases of the paranasal sinuses using digital diaphanoscopy

E. Bryanskaya, I. Makovik, A. Bukin, O. Bibikova, B. Shuraev, O. Minet, U. Zabarylo, A. Dunaev, V. Artyushenko

Proceedings Volume 11073, 110731P (2019) https://doi.org/10.1117/12.2526835

KEYWORDS: Magnetic resonance imaging, Visible radiation, Light scattering, Scattering, Pathology, Diagnostics, Image processing, Inflammation, Visualization, Tissue optics

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Proceedings Article | 4 March 2019 Presentation

Multi-spectral fiber spectroscopy methods as solutions for label-free medical diagnostics (Conference Presentation)

Olga Bibikova, Ervin Nippolainen, Isaac Afara, Julian Haas, Vesa Virtanen, Lasi Rieppo, Sonata Adomaviciute, Harold Brommer, René van Weeren, Anastasia Melenteva, Valeria Belikova, Urszula Zabarylo, Olaf Minet, Juha Töyräs, Valdas Sablinskas, Boris Mizaikoff, Viacheslav Artyushenko

Proceedings Volume 10890, 108901Q (2019) https://doi.org/10.1117/12.2509174

KEYWORDS: Tissues, Medical diagnostics, Spectroscopy, Spectroscopes, Fiber optics, Tissue optics, Kidney, Cartilage, Optical spectroscopy, Molecular spectroscopy

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Proceedings Article | 24 May 2018 Presentation

Single- and multispectral fiber probes as a solution for guided diagnostics and therapy (Conference Presentation)

Olga Bibikova, Urszula Zabarylo, Valeria Belikova, Anastasija Melenteva, Iskander Usenov, Thaddäus Hocotz, Tatiana Sakharova, Alexey Bocharnikov, Georgy Danielyan, Olaf Minet, Hans Eichler, Viacheslav Artyushenko

Proceedings Volume 10685, 106851K (2018) https://doi.org/10.1117/12.2307424

KEYWORDS: Diagnostics, Fluorescence spectroscopy, Luminescence, Fiber optics, Raman spectroscopy, Tissue optics, Spectroscopy, Cancer, Biopsy, Tissues

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Medical fiber optics as a part of laboratory and clinical diagnostic tools, surgical instrumentation and endoscopy should satisfy modern biomedical requirements. The flexibility, small size, bio-compatibility and feasibility to use sterilisable or disposable parts allow to apply fiber optic probes in clinical environment both ex-vivo and in-vivo. To enable spectroscopic differentiation cancer and normal tissue, we developed and applied various single and combined fiber optic probes using key spectroscopy methods such as Raman scattering, Mid IR-absorption, Diffuse NIR-reflection, and fluorescence in order to compare them and select the best combination for malignant detection of tissue in clinical environment. All four spectroscopic methods have been tested on biopsies of health and malignant tissues (colon and kidney) and bioliquids (serum, plasma and urine) of patients before and after surgery. The tiny Raman probe with 1.5 mm diameter has been developed for experimental ex-vivo tests. Further multivariate data analysis of spectroscopic data, both individual techniques and their combinations has provided a reliable cancer recognition for colon and kidney biopsies. The best synergic gain was observed of combining Mid IR-absorption and fluorescence spectroscopy (98% Sensitivity vs 63% or 88% for fluorescence or Mid IR-absorption correspondingly). Based on obtained results, both techniques were implemented within the same fiber probe to provide a simultaneous measurement of exactly the same spot at the sample surface. An innovative combi Fluo-ATR probe was designed, fabricated and tested. Diffuse NIR-reflection and fluorescence spectroscopy as the fastest measurement techniques were used for investigation of surgically removed colorectal tissue samples in a few minutes after resection. Taking into account the necessity of rapid measurement process, we developed multispectral NIR-UV probe that enables efficient excitation and collection of NIR diffuse reflectance and fluorescence spectra of the same point. Needle probe design with diameter 0.7 mm allows to penetrate in some depth of tissue and obtain most reliable spectra avoiding artefacts related to surface drying. Multivariate data analysis proved the increased sensitivity of methods combination in one dataset (94% Sensitivity vs 85% or 85% for fluorescence or NIR reflection correspondingly).

Proceedings Article | 4 March 2016 Presentation + Paper

LED-based near infrared sensor for cancer diagnostics

Andrey Bogomolov, Vladimir Ageev, Urszula Zabarylo, Iskander Usenov, Franziska Schulte, Dmitry Kirsanov, Valeria Belikova, Olaf Minet, E. Feliksberger, I. Meshkovsky, Viacheslav Artyushenko

Proceedings Volume 9715, 971510 (2016) https://doi.org/10.1117/12.2214342

KEYWORDS: Tumors, Sensors, Cancer, Tissues, Near infrared, Diagnostics, Spectroscopy, Data modeling, Kidney, Near infrared spectroscopy

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Proceedings Article | 15 July 2015 Paper

Spectral fiber sensors for cancer diagnostics in vitro

V. Artyushenko, F. Schulte, U. Zabarylo, H.-P. Berlien, I. Usenov, T. Saeb Gilani, H. Eichler, Ł. Pieszczek, A. Bogomolov, H. Krause, O. Minet

Proceedings Volume 9537, 953720 (2015) https://doi.org/10.1117/12.2183949

KEYWORDS: Cancer, Tissues, Raman spectroscopy, Tumors, Spectroscopy, Near infrared, Kidney, Principal component analysis, Diagnostics, Fiber optics

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Proceedings Article | 30 January 2014 Paper

Optical clearing of human skin for the enhancement of optical imaging of proximal interphalangeal joints

Ekaterina Kolesnikova, Aleksandr Kolesnikov, Urszula Zabarylo, Olaf Minet, Elina Genina, Alexey Bashkatov, Valery Tuchin

Proceedings Volume 9031, 90310C (2014) https://doi.org/10.1117/12.2049525

KEYWORDS: Skin, Tissues, Optical clearing, Tissue optics, Optical imaging, Urea, Biomedical optics, Refractive index, Semiconductor lasers, Light scattering

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Proceedings Article | 11 February 2010 Paper

Correction of motion artefacts and pseudo colour visualization of multispectral light scattering images for optical diagnosis of rheumatoid arthritis

Olaf Minet, Patrick Scheibe, Jürgen Beuthan, Urszula Zabarylo

Proceedings Volume 7547, 75470B (2010) https://doi.org/10.1117/12.852899

KEYWORDS: Light scattering, Image registration, Visualization, Diagnostics, Multispectral imaging, Image processing, RGB color model, Biomedical optics, Optical diagnostics, Laser scattering

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Proceedings Article | 9 June 2008 Paper

Optical monitoring of rheumatoid arthritis: Monte Carlo generated reconstruction kernels

O. Minet, J. Beuthan, A. Hielscher, U. Zabarylo

Proceedings Volume 6791, 67910G (2008) https://doi.org/10.1117/12.803975

KEYWORDS: Light scattering, Tissue optics, Scattering, Laser scattering, Deconvolution, Monte Carlo methods, Absorption, Skin, Point spread functions, Photons

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Proceedings Article | 26 April 2007 Paper

Measuring of optical properties of biological samples by low cost goniometrical equipment

M. Hoffmann, O. Schewtschenko, O. Minet

Proceedings Volume 6535, 65350I (2007) https://doi.org/10.1117/12.740805

KEYWORDS: Scattering, Light scattering, Monte Carlo methods, Goniophotometry, Geometrical optics, Particles, Absorption, Laser scattering, Photon transport, Tissues

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Proceedings Article | 21 July 2006 Paper

Laboratory test of mobile laser equipment for monitoring of water quality

Olaf Minet, Dang Xuan Cu, Nguyen Tuan Anh, Jürgen Beuthan, Gerhard Müller, Urszula Zabarylo

Proceedings Volume 6163, 61630N (2006) https://doi.org/10.1117/12.696984

KEYWORDS: Light scattering, Scattering, Absorption, Particles, Water, Tissue optics, Geometrical optics, Laser scattering, Integrating spheres, Optical properties

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SPIE Journal Paper | 1 July 2005 Open Access

Microscopical heat stress investigations under application of quantum dots

Cathrin Dressler, Olaf Minet, Jürgen Beuthan, Vladimir Novkov, Gerhard Müller

JBO, Vol. 10, Issue 04, 041209, (July 2005) https://doi.org/10.1117/12.10.1117/1.2001674

KEYWORDS: Luminescence, Plasma, Scanning electron microscopy, Cytoskeletons, Atomic force microscopy, Tissues, Microscopy, Control systems, Quantum dots, Heat treatments

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Proceedings Article | 4 March 1999 Paper

Research on human carcinoma cells in different physiological states using laser phase microscopy

Cathrin Dressler, Elena Perevedentseva, Juergen Beuthan, Olaf Minet, Evangelos Balanos, Georgi Graschew, Gerhard Mueller

Proceedings Volume 3726, (1999) https://doi.org/10.1117/12.341423

KEYWORDS: Bioalcohols, Microscopy, Phase shifts, Refractive index, Phase measurement, Biomedical optics, Objectives, Spatial resolution, Helium neon lasers, Mirrors

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Proceedings Article | 13 January 1998 Paper

RA diagnostics applying optical tomography in frequency-domain

Alexander Klose, Viravuth Prapavat, Olaf Minet, Juergen Beuthan, Gerhard Mueller

Proceedings Volume 3196, (1998) https://doi.org/10.1117/12.297920

KEYWORDS: Diagnostics, Optical tomography, Near infrared

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Proceedings Article | 6 December 1996 Paper

Extraction of optical tissue parameters in semi-infinite geometry using the PDW approach

Thomas Bocher, Hans-Georg Eberle, Rolf-Dieter Naber, Olaf Minet, Juergen Beuthan, Gerhard Mueller

Proceedings Volume 2925, (1996) https://doi.org/10.1117/12.260828

KEYWORDS: Tissue optics, Luminescence, Diffusion, Scattering, Modulation, Biomedical optics, Scanners, Phase shift keying, Tissues, Phase measurement

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Proceedings Article | 8 November 1996 Paper

Quantitative optical biopsy techniques in the time and frequency domain

Thomas Bocher, Gerhard Mueller, Olaf Minet, Juergen Beuthan

Proceedings Volume 2965, (1996) https://doi.org/10.1117/12.257382

KEYWORDS: Tissues, Luminescence, Tissue optics, Photons, Tumors, Fluorescence spectroscopy, Backscatter, Biopsy, Chromophores, Inflammation

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Proceedings Article | 24 April 1996 Paper

Diagnosis of inflammatory rheumatic diseases with photon density waves

Juergen Beuthan, Viravuth Prapavat, Rolf-Dieter Naber, Olaf Minet, Gerhard Mueller

Proceedings Volume 2676, (1996) https://doi.org/10.1117/12.238824

KEYWORDS: Modulation transfer functions, Tissue optics, Tissues, Modulation, Absorption, Diagnostics, Optical properties, Scattering, Imaging systems, X-rays

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Proceedings Article | 24 April 1996 Paper

Optical tomography of rat brain

Juergen Beuthan, Richard Freyer, Olaf Minet, Cuong Luu, Uwe Hampel, Rolf-Dieter Naber, Gerhard Mueller

Proceedings Volume 2676, (1996) https://doi.org/10.1117/12.238823

KEYWORDS: Optical tomography, Modulation, Brain, Scattering, Sensors, Modulation transfer functions, Light scattering, Tissue optics, Absorption, Inverse optics

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Proceedings Article | 9 February 1996 Paper

High-resolution coherent tomography

Klaus Doerschel, Olaf Minet, Gerhard Mueller

Proceedings Volume 2732, (1996) https://doi.org/10.1117/12.231690

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Proceedings Article | 10 January 1996 Paper

Specific heat capacities of human and animal tissues

K. Giering, I. Lamprecht, Olaf Minet

Proceedings Volume 2624, (1996) https://doi.org/10.1117/12.229547

KEYWORDS: Tissues, Tumors, In vitro testing, Laser therapeutics, Nitrogen, Liver, Skin, Liquids, Lung, Optical properties

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Proceedings Article | 27 December 1995 Paper

Combined quantitative and qualitative two-channel optical biopsy technique for discrimination of tumor borders

Thomas Bocher, Juergen Beuthan, M. Scheller, Juergen Hopf, Marietta Linnarz, Rolf-Dieter Naber, Olaf Minet, Wolfgang Becker, Gerhard Mueller

Proceedings Volume 2627, (1995) https://doi.org/10.1117/12.228882

KEYWORDS: Tissues, Tumors, Luminescence, Tissue optics, Chromophores, In vivo imaging, Inflammation, Backscatter, Biopsy, Laser induced fluorescence

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Proceedings Article | 18 December 1995 Paper

Frequency domain technique for a two-dimensional mapping of optical tissue properties

Thomas Bocher, Juergen Beuthan, Olaf Minet, Rolf-Dieter Naber, Gerhard Mueller

Proceedings Volume 2626, (1995) https://doi.org/10.1117/12.228676

KEYWORDS: Tissue optics, Luminescence, Scattering, Tissues, Photodetectors, Near field optics, Fluorescence spectroscopy, Modulation, Phase shift keying, Algorithm development

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Proceedings Article | 18 January 1995 Paper

Experimental set-up and Monte-Carlo model for the determination of optical tissue properties in the wavelength range 330 to 1100 nm

Andre Roggan, Hans Albrecht, Klaus Doerschel, Olaf Minet, Gerhard Mueller

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199205

KEYWORDS: Tissue optics, Collimation, Monte Carlo methods, Absorption, Optical properties, Tissues, Optical spheres, Photons, Scattering, Sensors

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Proceedings Article | 4 January 1995 Paper

Fiber optical sampling of NADH concentration in guinea pig hearts during ischemia

Thomas Bocher, Juergen Beuthan, Olaf Minet, Isabella Schmitt, B. Fuchs, Gerhard Mueller

Proceedings Volume 2324, (1995) https://doi.org/10.1117/12.198717

KEYWORDS: Luminescence, Tissues, Tissue optics, Backscatter, Heart, Anisotropy, Data acquisition, Fiber optics, Ischemia, Laser induced fluorescence

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Proceedings Article | 28 June 1994 Paper

Determination of optical tissue properties with double integrating sphere technique and Monte Carlo simulations

Andre Roggan, Olaf Minet, Christian Schroeder, Gerhard Mueller

Proceedings Volume 2100, (1994) https://doi.org/10.1117/12.179026

KEYWORDS: Tissue optics, Tissues, Optical spheres, Collimation, Monte Carlo methods, Optical properties, Absorption, Scattering, Integrating spheres, Sensors

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Proceedings Article | 19 May 1994 Paper

Investigations concerning the determination of NADH concentrations using optical biopsy

Juergen Beuthan, Thomas Bocher, Olaf Minet, Andre Roggan, Isabella Schmitt, A. Weber, Gerhard Mueller

Proceedings Volume 2135, (1994) https://doi.org/10.1117/12.176007

KEYWORDS: Luminescence, Tissue optics, Backscatter, Tissues, Laser induced fluorescence, Monte Carlo methods, Calibration, Biopsy, Signal detection, Data acquisition

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Proceedings Article | 15 January 1994 Paper

Infrared diaphanoscopy in medicine

Viravuth Prapavat, Juergen Beuthan, Marietta Linnarz, Olaf Minet, Juergen Hopf, Gerhard Mueller

Proceedings Volume 2081, (1994) https://doi.org/10.1117/12.166821

KEYWORDS: Tissue optics, Scattering, Biopsy, Tissues, Light scattering, Bone, Absorption, Light sources, Photons, Optical properties

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Proceedings Article | 14 September 1993 Paper

Imaging of oblique structures in scattering media by time-gated viewing and coherence imaging

Juergen Beuthan, Klaus Doerschel, Gerhard Mueller, Olaf Minet, B. Messer

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154676

KEYWORDS: Tissue optics, Tissues, Photons, Scattering media, Coherence imaging, Laser scattering, Geometrical optics, Scattering, Soft tissue optics, Switches

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Proceedings Article | 14 September 1993 Paper

Infrared diaphanoscopy and infrared fluoroscopic imaging in biological tissue

Juergen Beuthan, Gerhard Mueller, Olaf Minet, Andre Roggan, Viravuth Prapavat

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154672

KEYWORDS: Tissue optics, Tissues, Photons, Infrared imaging, Bone, Infrared radiation, Scattering, CCD cameras, Light scattering, Absorption

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Proceedings Article | 1 August 1992 Paper

Mathematical model of heat transfer in tissue compared with results from thermography, MRI and laser fluorescence spectroscopy

Juergen Beuthan, Gerhard Mueller, Olaf Minet, Hansjoerg Albrecht

Proceedings Volume 1649, (1992) https://doi.org/10.1117/12.60247

KEYWORDS: Tissue optics, Laser tissue interaction, Tissues, Mathematical modeling, Thermography, Magnetic resonance imaging, Laser therapeutics, Liver, Thermal modeling, Scattering

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Showing 5 of 32 publications

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