Dr. Mohsen Erfanzadeh Profile

Dr. Mohsen Erfanzadeh

SPIE Involvement:

Author

Optical and biomedical optics scientist with industry experience at consumer electronics optical metrology R&D (Apple) and semiconductor metrology (ASML) as well as academic experience in biomedical optics technologies including PS-OCT (Harvard Medical School) and Photoacoustic imaging, Spatial Frequency Domain Imaging, Tissue Optics (University of Connecticut).

SPIE Journal Paper | 17 April 2023 Open Access

Development of polarization-sensitive optical coherence tomography imaging platform and metrics to quantify electrostimulation-induced peripheral nerve injury in vivo in a small animal model

Guillermo Monroy, Mohsen Erfanzadeh, Michael Tao, Damon DePaoli, Ilyas Saytashev, Ahhyun Stephanie Nam, Harmain Rafi, Kasey Kwong, Katherine Shea, Benjamin Vakoc, Srikanth Vasudevan, Daniel Hammer

NPh, Vol. 10, Issue 02, 025004, (April 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.025004

KEYWORDS: Nerve, Optical coherence tomography, Coherence imaging, Animals, Nervous system, Injuries, Biological imaging, Optical imaging, Image segmentation, Tissue optics

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SignificanceNeuromodulation devices are rapidly evolving for the treatment of neurological diseases and conditions. Injury from implantation or long-term use without obvious functional losses is often only detectable through terminal histology. New technologies are needed that assess the peripheral nervous system (PNS) under normal and diseased or injured conditions.AimWe aim to demonstrate an imaging and stimulation platform that can elucidate the biological mechanisms and impacts of neurostimulation in the PNS and apply it to the sciatic nerve to extract imaging metrics indicating electrical overstimulation.ApproachA sciatic nerve injury model in a 15-rat cohort was observed using a newly developed imaging and stimulation platform that can detect electrical overstimulation effects with polarization-sensitive optical coherence tomography. The sciatic nerve was electrically stimulated using a custom-developed nerve holder with embedded electrodes for 1 h, followed by a 1-h recovery period, delivered at above-threshold Shannon model k-values in experimental groups: sham control (SC, n = 5, 0.0 mA / 0 Hz), stimulation level 1 (SL1, n = 5, 3.4 mA / 50 Hz, and k = 2.57), and stimulation level 2 (SL2, n = 5, 6.8 mA / 100 Hz, and k = 3.17).ResultsThe stimulation and imaging system successfully captured study data across the cohort. When compared to a SC after a 1-week recovery, the fascicle closest to the stimulation lead showed an average change of +4 % / − 309 % (SL1/SL2) in phase retardation and −79 % / − 148 % in optical attenuation relative to SC. Analysis of immunohistochemistry (IHC) shows a +1 % / − 36 % difference in myelin pixel counts and −13 % / + 29 % difference in axon pixel counts, and an overall increase in cell nuclei pixel count of +20 % / + 35 % . These metrics were consistent with IHC and hematoxylin/eosin tissue section analysis.ConclusionsThe poststimulation changes observed in our study are manifestations of nerve injury and repair, specifically degeneration and angiogenesis. Optical imaging metrics quantify these processes and may help evaluate the safety and efficacy of neuromodulation devices.

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Proceedings Article | 10 March 2020 Presentation

Wide-field intraoperative polarization sensitive and angiographic optical coherence tomography of in vivo non-human primate peripheral nerve (Conference Presentation)

Mohsen Erfanzadeh, Ahhyun Nam, Marek Hansdorfer, Kasey Kwong, Mark Randolph, Robert Redmond, Benjamin Vakoc

Proceedings Volume 11251, 112510M (2020) https://doi.org/10.1117/12.2544939

KEYWORDS: Nerve, Optical coherence tomography, Angiography, In vivo imaging, Polarization, Tissue optics, Picosecond phenomena, Axons, Molecules, Birefringence

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Proceedings Article | 1 March 2019 Paper

A multi spectral hand-held spatial frequency domain imaging system for imaging human colorectal cancer

Yifeng Zeng, Shuying Li, Mohsen Erfanzadeh, Sreyankar Nandy, William Chapman, Zahra Alipour, Heba Abdelal, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Proceedings Volume 10874, 108740T (2019) https://doi.org/10.1117/12.2510320

KEYWORDS: Imaging systems, Tissues, Colorectal cancer, Colon, Tumors, Absorption, Scattering, Medicine, Biomedical engineering, Pathology, Diffuse optical imaging, Rectum, Spatial frequencies, Structured light

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Proceedings Article | 27 March 2017 Paper

Feasibility study of spatial frequency domain imaging using a handheld miniaturized projector and rigid endoscope

Sreyankar Nandy, Mohsen Erfanzadeh, Feifei Zhou, Quing Zhu

Proceedings Volume 10059, 100591S (2017) https://doi.org/10.1117/12.2253221

KEYWORDS: Projection systems, Endoscopes, Tissues, Endoscopy, Imaging systems, Spatial frequencies, Calibration, In vivo imaging, Absorption, Scattering, Surgery, Oxygen, Tumors, Optical properties

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Proceedings Article | 3 March 2017 Paper

A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent

Mohsen Erfanzadeh, Michael Luciano, Feifei Zhou, Christian Brückner, Quing Zhu

Proceedings Volume 10064, 1006432 (2017) https://doi.org/10.1117/12.2249877

KEYWORDS: In vivo imaging, Photoacoustic tomography, Acquisition tracking and pointing, Luminescence, Blood, Absorbance, Photoacoustic spectroscopy, Absorption, Near infrared, Toxicity, Tumors, Argon, Signal generators

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Proceedings Article | 3 March 2017 Paper

Low-cost laser scanning photoacoustic microscopy system with a pulsed laser diode excitation source

Mohsen Erfanzadeh, Quing Zhu

Proceedings Volume 10064, 100644R (2017) https://doi.org/10.1117/12.2249618

KEYWORDS: Laser tissue interaction, Semiconductor lasers, Laser scanners, Photoacoustic microscopy, Imaging systems, Collimation, Laser systems engineering, Aspheric lenses, Tissues, Solid state lasers, Ear, Image resolution, Signal to noise ratio, Data acquisition, Tissue optics, Ultrasonography

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Proceedings Article | 15 March 2016 Paper

Improvement and evaluation of a low-cost laser diode photoacoustic microscopy system for ovarian tissue imaging

Mohsen Erfanzadeh, Hassan Salehi, Patrick Kumavor, Quing Zhu

Proceedings Volume 9708, 97083I (2016) https://doi.org/10.1117/12.2208943

KEYWORDS: Imaging systems, Semiconductor lasers, Photoacoustic microscopy, Tissue optics, Aspheric lenses, Signal to noise ratio, Tissues, Laser tissue interaction, Laser sources, Collimation, Ovary, Ear, Blood

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