Dr. Michal R. Tomaszewski Profile

Dr. Michal R. Tomaszewski

Doctoral Candidate at Merck & Co Inc

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Publications (7)

Proceedings Article | 2 April 2024 Presentation + Paper

Universal 3D CT lesion segmentation using SAM with RECIST annotation

Yiqiao Liu, Sarah Halek, Lin Li, Michal Tomaszewski, Shubing Wang, Richard Baumgartner, Jianda Yuan, Gregory Goldmacher, Antong Chen

Proceedings Volume 12926, 1292605 (2024) https://doi.org/10.1117/12.3006527

KEYWORDS: Deep learning, Oncology, Image segmentation, Computed tomography

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Proceedings Article | 3 March 2017 Presentation + Paper

Quantitative imaging of tumor vasculature using multispectral optoacoustic tomography (MSOT)

Michal Tomaszewski, Isabel Quiros-Gonzalez, James Joseph, Sarah Bohndiek

Proceedings Volume 10064, 100640N (2017) https://doi.org/10.1117/12.2251865

KEYWORDS: Oxygen, Tomography, Cancer, Oncology, Radiotherapy, Optical tomography, Optical imaging, Spatial resolution, Ultrasonography, Modulation, Tumors, Chromophores, Blood, Tissue optics, Image segmentation

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The ability to evaluate tumor oxygenation in the clinic could indicate prognosis and enable treatment monitoring, since oxygen deficient cancer cells are often more resistant to chemotherapy and radiotherapy. MultiSpectral Optoacoustic Tomography (MSOT) is a hybrid technique combining the high contrast of optical imaging with spatial resolution and penetration depth similar to ultrasound. We hypothesized that MSOT could reveal both tumor vascular density and function based on modulation of blood oxygenation.

We performed MSOT on nude mice (n=8) bearing subcutaneous xenograft PC3 tumors using an inVision 256 (iThera Medical). The mice were maintained under inhalation anesthesia during imaging and respired oxygen content was modified from 21% to 100% and back. After imaging, Hoechst 33348 was injected to indicate vascular perfusion and permeability. Tumors were then extracted for histopathological analysis and fluorescence microscopy. The acquired data was analyzed to extract a bulk measurement of blood oxygenation (SO₂^MSOT) from the whole tumor using different approaches. The tumors were also automatically segmented into 5 regions to investigate the effect of depth on SO₂^MSOT.

Baseline SO₂^MSOT values at 21% and 100% oxygen breathing showed no relationship with ex vivo measures of vascular density or function, while the change in SO₂^MSOT showed a strong negative correlation to Hoechst intensity (r=- 0.92, p=0.0016). Tumor voxels responding to oxygen challenge were spatially heterogeneous. We observed a significant drop in SO2 MSOT value with tumor depth following a switch of respiratory gas from air to oxygen (0.323±0.017 vs. 0.11±0.05, p=0.009 between 0 and 1.5mm depth), but no such effect for air breathing (0.265±0.013 vs. 0.19±0.04, p=0.14 between 0 and 1.5mm depth).

Our results indicate that in subcutaneous prostate tumors, baseline SO₂^MSOT levels do not correlate to tumor vascular density or function while the magnitude of the response to oxygen challenge provides insight into these parameters. Future work will include validation using in vivo imaging and protocol optimization for clinical application.

Proceedings Article | 15 March 2016 Presentation + Paper

In vivo light fluence correction for determination of tissue absorption coefficient using Multispectral Optoacoustic Tomography

Frederic Brochu, James Joseph, Michal Tomaszewski, Sarah Bohndiek

Proceedings Volume 9708, 970829 (2016) https://doi.org/10.1117/12.2210958

KEYWORDS: Absorption, Tissue optics, In vivo imaging, Tomography, Scattering, Tissues, Image segmentation, Optical imaging, Light scattering, Ultrasonography, Chromophores

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Proceedings Article | 15 March 2016 Presentation + Paper

Measurement of changes in blood oxygenation using Multispectral Optoacoustic Tomography (MSOT) allows assessment of tumor development

Michal Tomaszewski, Isabel Quiros-Gonzalez, James Joseph, Sarah Bohndiek

Proceedings Volume 9708, 97081F (2016) https://doi.org/10.1117/12.2208913

KEYWORDS: Tumors, Tomography, Oxygen, Blood, Blood vessels, Tissues, Imaging systems, Tissue optics, Cancer, Ultrasonography

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Proceedings Article | 16 July 2015 Paper

Light fluence correction for quantitative determination of tissue absorption coefficient using multi-spectral optoacoustic tomography

Frederic Brochu, James Joseph, Michal Tomaszewski, Sarah Bohndiek

Proceedings Volume 9539, 95390Z (2015) https://doi.org/10.1117/12.2182416

KEYWORDS: Absorption, Data modeling, Image segmentation, Chromophores, Tissue optics, Scattering, Transducers, Tomography, In vivo imaging, Ultrasonography

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Proceedings Article | 11 March 2015 Paper

Evaluation of MultiSpectral Optoacoustic Tomography (MSOT) performance in phantoms and in vivo

James Joseph, Michal Tomaszewski, Fiona Morgan, Sarah Bohndiek

Proceedings Volume 9323, 93230J (2015) https://doi.org/10.1117/12.2077501

KEYWORDS: Imaging systems, In vivo imaging, Spleen, Kidney, Tomography, Oxygen, Signal detection, Tumors, Cancer, Optical imaging

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Proceedings Article | 26 April 2006 Paper

Camera calibration by linear decomposition

Wladyslaw Skarbek, Michal Tomaszewski, Artur Nowakowski

Proceedings Volume 6159, 61593D (2006) https://doi.org/10.1117/12.674883

KEYWORDS: Cameras, Calibration, Digital cameras, 3D modeling, Californium, Information technology, Reconstruction algorithms, Electronics, Photonics, Astronomy

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Showing 5 of 7 publications

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