Both new and established technologies are explored in the pursuit of finding an efficient approach for diagnosing malignant melanoma skin cancer. The non-invasive sub-surface imaging technique of optical coherence tomography (OCT) is frequently applied in the ophthalmological clinic, but is still emerging within the field of dermatology. We present our work in testing two supercontinuum OCT systems for characterizing tape strips applied to skin cancer patients. Tape strips were collected in a clinical trial of 75 skin cancer patients at Bispebjerg Hospital, Denmark. After low-temperature storage, samples were scanned by a near-infrared OCT system and a mid-infrared OCT system of wavelengths 1.3 µm and 4 µm. We report on the scanning protocol and how the wavelength dependent OCT scans can be interpreted in order to target malignant melanoma characteristics.
New advanced imaging technologies can improve the accuracy of skin cancer diagnosis, reducing the risk of misdiagnosis and unnecessary excision. We explore reflectance confocal microscopy (RCM) and photoacoustic imaging (PAI) for fast, precise skin cancer diagnosis at the bedside.
75 patients with suspicious pigmented skin lesions were scanned with RCM and PAI prior to excision. Dermoscopy images were obtained prior to scanning. Morphological features and blood vessel characteristics were analysed and diagnostic accuracy assessed. Tumour thickness, blood flow, collagen, lipid and melanin content were measured by PAI. New diagnostic hypotheseses, combining PAI, RCM and dermoscopy, will be presented.
The combination of PAI and RCM offers high-resolution and deep penetration visualization of skin structures, facilitating accurate diagnosis and assessment of suspicious skin tumors at first patient visit. This approach can potentially reduce invasive procedures and the risk of misdiagnosis.
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