Prof. Maria Lepore Profile

Prof. Maria Lepore

Associate Professor at Univ degli Studi della Campania Luigi Vanvitelli

SPIE Involvement:

Author

Area of Expertise:

optical properties of biological tissue , fluorescence spectroscopy , Raman spectroscopy , infrared spectroscopy , optical biosensors

Websites:

Company Website

Publications (48)

Proceedings Article | 11 August 2023 Paper

Characterization of lipid components in human cells by means of ATR FT-IR spectroscopy

Bahar Faramarzi, Marianna Portaccio, Ines Delfino, Maria Lepore

Proceedings Volume 12627, 126272Q (2023) https://doi.org/10.1117/12.2670762

KEYWORDS: FT-IR spectroscopy, Biological samples, Attenuated total reflectance, Infrared radiation, Temperature metrology, Spectroscopy, Spectral resolution, Picosecond phenomena, Pathology, Infrared spectroscopy

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Proceedings Article | 11 August 2023 Paper

An investigation on the Amide I band in vibrational spectra of gingival crevicular fluid during orthodontic treatments

Carlo Camerlingo, Marianna Portaccio, Fabrizia d'Apuzzo, Ludovica Nucci, Letizia Perillo, Ines Delfino, Maria Lepore

Proceedings Volume 12627, 1262732 (2023) https://doi.org/10.1117/12.2670584

KEYWORDS: Vibration, Raman spectroscopy, Surface enhanced Raman spectroscopy, Spectroscopy, Microfluidics, FT-IR spectroscopy, Ranging, Proteins, Molecular spectroscopy, Molecular aggregates

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SPIE Journal Paper | 6 August 2020 Open Access

Surface-enhanced Raman spectroscopy of tears: toward a diagnostic tool for neurodegenerative disease identification

Gilda Cennamo, Daniela Montorio, Vincenzo Brescia Morra, Chiara Criscuolo, Roberta Lanzillo, Elena Salvatore, Carlo Camerlingo, Mikhail Lisitskiy, Ines Delfino, Marianna Portaccio, Maria Lepore

JBO, Vol. 25, Issue 08, 087002, (August 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.8.087002

KEYWORDS: Surface enhanced Raman spectroscopy, Proteins, Raman spectroscopy, Diagnostics, Principal component analysis, Dementia, Deconvolution, Pathology, Brain

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Proceedings Article | 16 April 2020 Presentation + Paper

Different approaches for Raman spectra multivariate analysis for monitoring x-rays exposed human neuroblastoma cells

Ines Delfino, Valerio Ricciardi, Giuseppe Perna, Maria Lasalvia, Lorenzo Manti, Vito Capozzi, Maria Lepore

Proceedings Volume 11359, 113591K (2020) https://doi.org/10.1117/12.2555170

KEYWORDS: Raman spectroscopy, Principal component analysis, X-rays, Proteins, Biological research, Data analysis, Radiation effects, Statistical analysis, Ionizing radiation, Tissues

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Proceedings Article | 19 July 2019 Paper

X-ray irradiation effects on SH-SY5Y human neuroblastoma cells monitored by means of FTIR micro-spectroscopy

Valerio Ricciardi, Marianna Portaccio, Lorenzo Manti, Maria Lepore

Proceedings Volume 11073, 110731M (2019) https://doi.org/10.1117/12.2526399

KEYWORDS: Proteins, FT-IR spectroscopy, Deconvolution, X-rays, Statistical analysis, Biological research, Infrared radiation, Cancer, Radiotherapy

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Proceedings Article | 19 July 2019 Paper

Raman micro-spectroscopy investigation on the effects of x-rays and polyphenols in human neuroblastoma cells

Valerio Ricciardi, Giuseppe Perna, Maria Lasalvia, Ines Delfino, Lorenzo Manti, Simona Piccolella, Severina Pacifico, Vito Capozzi, Maria Lepore

Proceedings Volume 11073, 1107310 (2019) https://doi.org/10.1117/12.2526590

KEYWORDS: X-rays, Raman spectroscopy, Proteins, Tumors, Statistical analysis, In vitro testing, Radiotherapy, Ionizing radiation, Spectral resolution, Visible radiation

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Proceedings Article | 19 July 2019 Paper

Monitoring x-rays exposed and unexposed cell culture media by means of surface-enhanced Raman spectroscopy

Ines Delfino, Carlo Camerlingo, Maria Lepore

Proceedings Volume 11073, 110731V (2019) https://doi.org/10.1117/12.2526598

KEYWORDS: Surface enhanced Raman spectroscopy, X-rays, Glucose, Raman spectroscopy, Proteins, Deconvolution, Wavelets, Liquids, Biological research, Ionizing radiation

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Proceedings Article | 17 May 2018 Paper

Optical monitoring of cell migration processes in a 3D scaffold

Ines Delfino, Marianna Portaccio, Antonella D'Agostino, Marcella Cammarota, Ferdinando Campitiello, Chiara Schiraldi, Maria Lepore

Proceedings Volume 10685, 106853X (2018) https://doi.org/10.1117/12.2306982

KEYWORDS: Collagen, Polymers, Scanning electron microscopy, 3D modeling, Tissues, Two photon excitation microscopy, Tissue engineering, Tissue optics, Proteins, Confocal microscopy

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Proceedings Article | 17 May 2018 Paper

Dynamical and structural properties of flavin adenine dinucleotide in aqueous solutions

Ines Delfino, Rosario Esposito, Marianna Portaccio, Maria Lepore

Proceedings Volume 10685, 106854N (2018) https://doi.org/10.1117/12.2306990

KEYWORDS: Picosecond phenomena, Time resolved spectroscopy, FT-IR spectroscopy, Luminescence, Microelectromechanical systems, Circular dichroism spectroscopy, Fluorescence spectroscopy, Dichroic materials, Solids, Optical properties

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SPIE Journal Paper | 6 November 2017 Open Access

Monitoring early phases of orthodontic treatment by means of Raman spectroscopies

Fabrizia d’Apuzzo, Letizia Perillo, Ines Delfino, Marianna Portaccio, Maria Lepore, Carlo Camerlingo

JBO, Vol. 22, Issue 11, 115001, (November 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.11.115001

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Statistical analysis, Biological research, Teeth, Proteins, Bone, Deconvolution, Imaging spectroscopy, Motion analysis

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SPIE Journal Paper | 13 March 2015 Open Access

Visible micro-Raman spectroscopy of single human mammary epithelial cells exposed to x-ray radiation

Ines Delfino, Giuseppe Perna, Maria Lasalvia, Vito Capozzi, Lorenzo Manti, Carlo Camerlingo, Maria Lepore

JBO, Vol. 20, Issue 03, 035003, (March 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.3.035003

KEYWORDS: Principal component analysis, Proteins, Raman spectroscopy, Micro raman spectroscopy, X-rays, Statistical analysis, Visible radiation, Glasses, Signal processing, Cancer

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Proceedings Article | 22 February 2013 Paper

A preliminary investigation on the interaction between sol-gel immobilized glucose oxidase and freely diffusing glucose by means of two-photon microscopy

I. Delfino, M. Portaccio, M. De Rosa, M. Lepore

Proceedings Volume 8588, 85882U (2013) https://doi.org/10.1117/12.2006347

KEYWORDS: Glucose, Sol-gels, Luminescence, Absorption, Microscopes, FT-IR spectroscopy, Two photon excitation microscopy, Proteins, Confocal microscopy, Molecules

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Proceedings Article | 9 May 2012 Paper

Optical properties of sol-gel immobilized Laccase: a first step for its use in optical biosensing

I. Delfino, M. Portaccio, B. Della Ventura, G. Manzo, D. G. Mita, M. Lepore

Proceedings Volume 8439, 84391X (2012) https://doi.org/10.1117/12.921396

KEYWORDS: Sol-gels, Optical properties, Luminescence, Raman spectroscopy, Copper, FT-IR spectroscopy, Absorption, Biosensing, Matrices, Oxidation

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Proceedings Article | 8 May 2012 Paper

X-ray radiation-induced effects in human mammary epithelial cells investigated by Raman microspectroscopy

R. Risi, L. Manti, G. Perna, M. Lasalvia, V. Capozzi, I. Delfino, M. Lepore

Proceedings Volume 8427, 84272E (2012) https://doi.org/10.1117/12.921389

KEYWORDS: Raman spectroscopy, Proteins, X-rays, Micro raman spectroscopy, Glasses, Imaging spectroscopy, Hydrogen, Deconvolution, Inspection, Confocal microscopy

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Proceedings Article | 18 May 2010 Paper

Micro-Raman spectroscopy of tissue samples for oral pathology follow-up monitoring

I. Delfino, C. Camerlingo, F. Zenone, G. Perna, V. Capozzi, N. Cirillo, G. Gaeta, M. Lepore

Proceedings Volume 7715, 77152J (2010) https://doi.org/10.1117/12.852803

KEYWORDS: Raman spectroscopy, Tissues, Photovoltaics, Wavelets, Pathology, Micro raman spectroscopy, Biopsy, In vivo imaging, Signal processing, Deconvolution

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Proceedings Article | 18 May 2010 Paper

FT-IR microspectroscopy characterization of supports for enzyme immobilization in biosensing applications

M. Portaccio, B. Della Ventura, K. Gabrovska, I. Marinov, T. Godjevargova, D. Mita, M. Lepore

Proceedings Volume 7715, 77153P (2010) https://doi.org/10.1117/12.852804

KEYWORDS: FT-IR spectroscopy, Sol-gels, Biosensing, Spectroscopy, Matrices, Infrared spectroscopy, Glucose, Infrared radiation, Silica, Molecules

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Proceedings Article | 23 February 2009 Paper

One- and two-photon time-resolved fluorescence of visible and near-infrared dyes in scattering media

R. Esposito, C. Altucci, R. Velotta, G. M. Gaeta, M. Lepore

Proceedings Volume 7169, 71691J (2009) https://doi.org/10.1117/12.810006

KEYWORDS: Luminescence, Scattering, Time resolved spectroscopy, Scattering media, Absorption, Visible radiation, Diagnostics, Photons, Picosecond phenomena, Electromagnetic scattering

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Proceedings Article | 18 February 2009 Paper

Oral pathology follow-up by means of micro-Raman spectroscopy on tissue and blood serum samples: an application of wavelet and multivariate data analysis

I. Delfino, C. Camerlingo, F. Zenone, G. Perna, V. Capozzi, N. Cirillo, G. Gaeta, E. De Mol, M. Lepore

Proceedings Volume 7162, 71620L (2009) https://doi.org/10.1117/12.808863

KEYWORDS: Raman spectroscopy, Photovoltaics, Blood, Tissues, Wavelets, Data modeling, Micro raman spectroscopy, Calibration, Tissue optics, Data analysis

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Proceedings Article | 27 February 2008 Paper

Wavelet data analysis of micro-Raman spectra for follow-up monitoring in oral pathologies

C. Camerlingo, F. Zenone, G. Perna, V. Capozzi, N. Cirillo, G. Gaeta, M. Lepore

Proceedings Volume 6843, 68430K (2008) https://doi.org/10.1117/12.769357

KEYWORDS: Raman spectroscopy, Tissues, Photovoltaics, Wavelets, Biopsy, Blood, Micro raman spectroscopy, Pathology, Signal processing, Data analysis

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Proceedings Article | 21 February 2008 Paper

Static and dynamic light scattering properties of Intralipid aqueous suspension for tissue phantom preparation and calibration

I. Delfino, R. Esposito, B. Piccirillo, G. M. Gaeta, M. Lepore

Proceedings Volume 6870, 68700P (2008) https://doi.org/10.1117/12.769364

KEYWORDS: Light scattering, Scattering, Mie scattering, Dynamic light scattering, Tissue optics, Optical properties, Transmittance, Diffusion, Signal detection, Laser sintering

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Proceedings Article | 8 March 2007 Paper

Oral pathology diagnosis by means of micro-Raman spectroscopy on biopsies and blood serum

F. Zenone, M. Lepore, G. Perna, P. Carmone, I. Delfino, G. Gaeta, V. Capozzi

Proceedings Volume 6425, 64250V (2007) https://doi.org/10.1117/12.708142

KEYWORDS: Raman spectroscopy, Tissues, Blood, Pathology, Connective tissue, Proteins, Biopsy, Micro raman spectroscopy, Photovoltaics, Tissue optics

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Proceedings Article | 1 March 2007 Paper

Spatially varying absorptive or scattering inclusions in a diffusive slab: a perturbation approach to the time-resolved transmittance

Rosario Esposito, Sergio De Nicola, Maria Lepore

Proceedings Volume 6434, 64342D (2007) https://doi.org/10.1117/12.708133

KEYWORDS: Scattering, Transmittance, Diffusion, Finite element methods, Tissues, Absorption, Light scattering, Optical properties, Near infrared, Breast

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Proceedings Article | 6 February 2007 Paper

Laser sources in dentistry and radiation safety regulations

D. De Luca, G. Gaeta, M. Lepore

Proceedings Volume 6430, 64301P (2007) https://doi.org/10.1117/12.708440

KEYWORDS: Laser dentistry, Nominal ocular hazard distance, Laser safety, Safety, Standards development, Skin, Laser sources, Dentistry, Er:YAG lasers, Eye

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Proceedings Article | 20 April 2006 Paper

Light scattering processes in nematic liquid crystals without alignment control

B. Piccirillo, M. Lepore, E. Santamato

Proceedings Volume 6192, 619237 (2006) https://doi.org/10.1117/12.663732

KEYWORDS: Light scattering, Liquid crystals, Scattering, Diffusion, Transmittance, Scatter measurement, Sensors, Streak cameras, Optical fibers, Temperature metrology

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Proceedings Article | 14 April 2006 Paper

Image quality in time-resolved laser transillumination by time-correlated single photon counting

A. Daniele, M. Mormile, R. Esposito, M. Lepore, P. Indovina

Proceedings Volume 6191, 61911R (2006) https://doi.org/10.1117/12.663729

KEYWORDS: Spatial resolution, Imaging systems, Image quality, Scattering, Picosecond phenomena, Sensors, Optical imaging, Photons, Signal to noise ratio, Streak cameras

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Proceedings Article | 15 February 2006 Paper

Micro-Raman spectroscopy on oral tissues

F. Zenone, M. Lepore, G. Perna, P. Carmone, R. Riccio, G. Gaeta, V. Capozzi

Proceedings Volume 6137, 61370P (2006) https://doi.org/10.1117/12.651678

KEYWORDS: Tissues, Raman spectroscopy, Biopsy, Biological research, Pathology, Micro raman spectroscopy, Proteins, Connective tissue, In vivo imaging, Remote sensing

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Proceedings Article | 15 February 2006 Paper

Micro-Raman spectroscopy and E-SEM analysis of hybrid layer at the dentine/resin interface of three different composite restorative resins

C. Camerlingo, G. Gaeta, R. Riccio, F. Rosso, L. Muscariello, M. Lepore

Proceedings Volume 6137, 61370I (2006) https://doi.org/10.1117/12.640317

KEYWORDS: Composites, Interfaces, Teeth, Micro raman spectroscopy, Raman spectroscopy, Laser ablation, Diamond, Composite resins, Image processing, Diffusion

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Proceedings Article | 7 June 2005 Paper

Image quality in optical imaging by time-correlated single photon-counting technique

M. Mormile, R. Esposito, R. Romano, M. Lepore, P. Indovina

Proceedings Volume 5850, (2005) https://doi.org/10.1117/12.633537

KEYWORDS: Spatial resolution, Imaging systems, Optical imaging, Signal to noise ratio, Picosecond phenomena, Scattering, Image quality, Photons, Light scattering, Sensors

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Proceedings Article | 28 April 2005 Paper

A perturbation approach for optical characterization of absorptive inclusions in diffusing media by time-resolved contrast measurements

R. Esposito, S. De Nicola, M. Lepore, I. Delfino, P. Indovina

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.594469

KEYWORDS: Absorption, Scattering, Transmittance, Optical properties, Diffusion, Geometrical optics, Tissues, Sensors, Finite element methods, Tissue optics

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Proceedings Article | 23 March 2005 Paper

Data analysis in Raman measurements of biological tissues using wavelet techniques

Giovanni Gaeta, Flora Zenone, Carlo Camerlingo, Roberto Riccio, Gianfranco Moro, Maria Lepore, Pietro Indovina

Proceedings Volume 5687, (2005) https://doi.org/10.1117/12.593394

KEYWORDS: Tissues, Raman spectroscopy, Wavelets, Signal processing, Discrete wavelet transforms, Proteins, Pathology, Interference (communication), Spectroscopy, Data analysis

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Proceedings Article | 19 November 2003 Paper

Theoretical and experimental investigations on image quality in optical imaging by time-resolved techniques

Rosario Esposito, Ines Delfino, Maria Lepore, Pietro Indovina

Proceedings Volume 4829, (2003) https://doi.org/10.1117/12.523983

KEYWORDS: Image quality, Spatial resolution, Optical properties, Reconstruction algorithms, Scattering, Photons, Optical imaging, Absorption, Imaging systems, Image transmission

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Proceedings Article | 29 July 2003 Paper

Random walk analysis of time-resolved transmittance measurements

Ines Delfino, Maria Lepore, Pietro Indovina

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.476800

KEYWORDS: Scattering, Transmittance, Absorption, Diffusion, Optical properties, Light scattering, Laser scattering, Refractive index, Data modeling, Optical testing

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Proceedings Article | 29 July 2003 Paper

Imaging small inhomogeneities by time-resolved laser transmittance measurements using different reconstruction procedures

Rosario Esposito, Maria Lepore, Ines Delfino, Pietro Indovina

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.476857

KEYWORDS: Signal to noise ratio, Absorption, Scattering, Reconstruction algorithms, Transmittance, Picosecond phenomena, Photons, Diffusion, Optical properties, Tissue optics

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Proceedings Article | 3 July 2003 Paper

Raman spectroscopy on dentin/resin interface of lased and unlased dental samples

Carlo Camerlingo, Giovanni Gaeta, Maria Lepore, Roberto Riccio

Proceedings Volume 4950, (2003) https://doi.org/10.1117/12.476459

KEYWORDS: Raman spectroscopy, Interfaces, Teeth, Laser drilling, Micro raman spectroscopy, Scanning electron microscopy, Visible radiation, Er:YAG lasers, Laser dentistry, Helium neon lasers

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Proceedings Article | 28 May 2002 Paper

Preparation and characterization of phantom objects for optical imaging by time-resolved transmittance and fluorescence

Laura Bottalico, Ines Delfino, Rosario Esposito, Maria Lepore

Proceedings Volume 4622, (2002) https://doi.org/10.1117/12.468357

KEYWORDS: Luminescence, Transmittance, Scattering, Optical imaging, Imaging systems, Rhodamine, Picosecond phenomena, Optical properties, Time resolved spectroscopy, Data acquisition

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Proceedings Article | 2 November 2001 Paper

Small volume approximation in first-order perturbative approach to the diffusion equation

Rosario Esposito, Maria Lepore, Pietro Indovina

Proceedings Volume 4431, (2001) https://doi.org/10.1117/12.447440

KEYWORDS: Transmittance, Optical properties, Diffusion, Photons, Scattering, Absorption, Numerical integration, Geometrical optics, Light scattering, Signal to noise ratio

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SPIE Journal Paper | 1 October 2001 Open Access

Depth dependence of the analytical expression for the width of the point spread function (spatial resolution) in time-resolved transillumination

Victor Chernomordik, Amir Gandjbakhche, Maria Lepore, Rosario Esposito, Ines Delfino

JBO, Vol. 6, Issue 04, (October 2001) https://doi.org/10.1117/12.10.1117/1.1412225

KEYWORDS: Spatial resolution, Point spread functions, Scattering, Tissue optics, Picosecond phenomena, Data modeling, Statistical analysis, Optical imaging, Image resolution, Streak cameras

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Proceedings Article | 29 June 2001 Paper

Development of a time-domain tomographic system for optical imaging

Maria Lepore, Gaetano Urso, Rosario Esposito, Laura Bottalico, M. Esposito, Maria Falco, Ines Delfino, Pietro Indovina

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434532

KEYWORDS: Imaging systems, Optical imaging, Spatial resolution, Picosecond phenomena, Sensors, Scattering, Diffusion, Tomography, Optical properties, Single photon

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Proceedings Article | 22 November 2000 Paper

Optical property measurements in scattering media by time-correlated single-photon counting system (TCSPCS)

Gaetano Urso, Maria Lepore, Pietro Indovina

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407631

KEYWORDS: Convolution, Mie scattering, Optical properties, Imaging systems, Diffusion, Sensors, Semiconductor lasers, Picosecond phenomena, Tissues, Scattering

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Proceedings Article | 22 November 2000 Paper

Differences in optical properties of normal and tumoral tissues: a comparison to accuracy limits in laser techniques for optical imaging

Maria Falco, Maria Lepore, Pietro Indovina

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407635

KEYWORDS: Tissues, Tissue optics, Optical properties, Optical imaging, Absorption, Scattering, Breast, Mie scattering, In vitro testing

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Proceedings Article | 16 November 2000 Paper

Fluorescence spectroscopy of scattering media in visible and infrared range

Maria Lepore, Simonetta Grilli, Pietro Indovina

Proceedings Volume 4161, (2000) https://doi.org/10.1117/12.409328

KEYWORDS: Luminescence, Scattering, Tissues, Visible radiation, Scattering media, Fluorescence spectroscopy, Infrared spectroscopy, Infrared radiation, Data modeling, Light scattering

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Proceedings Article | 17 May 2000 Paper

Edge response function in optical imaging by time-resolved laser transillumination

Maria Lepore, Rosario Esposito, Pietro Indovina

Proceedings Volume 3907, (2000) https://doi.org/10.1117/12.386305

KEYWORDS: Spatial resolution, Image quality, Reconstruction algorithms, Signal to noise ratio, Imaging systems, Optical imaging, Scattering, Optical properties, Picosecond phenomena, Photons

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Proceedings Article | 15 July 1999 Paper

Experimental comparison between time-resolved transmittance and reflectance techniques for optical characterization of scattering media

Maria Lepore, Ines Delfino, Antonio Ramaglia, Francesco Vigilante, Pietro Indovina

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356836

KEYWORDS: Transmittance, Reflectivity, Sensors, Latex, Streak cameras, Photon counting, Semiconductor lasers, Scattering media, Diffusion, Imaging systems

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Proceedings Article | 15 January 1999 Paper

Time-resolved transmittance for the noninvasive determination of tissue optical properties

Sergio De Nicola, Maria Falco, Maria Lepore

Proceedings Volume 3570, (1999) https://doi.org/10.1117/12.336942

KEYWORDS: Transmittance, Tissue optics, Diffusion, Optical properties, Scattering, Interfaces, Tissues, Light scattering, Biomedical optics, Absorption

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Proceedings Article | 16 April 1998 Paper

Systematic investigation of time-resolved transmittance technique for optical characterization of scattering media

Maria Lepore, Ines Delfino, Daniela Falco, Antonio Ramaglia, Gaetano Urso, Francesco Vigilante, Pietro Indovina

Proceedings Volume 3250, (1998) https://doi.org/10.1117/12.305376

KEYWORDS: Transmittance, Mie scattering, Scattering, Laser scattering, Latex, Optical properties, Breast, Particles, Scattering media, Absorption

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Proceedings Article | 1 January 1998 Paper

Optical properties of scattering solutions by time-resolved transmittance spectroscopy

Ines Delfino, Maria Lepore

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301074

KEYWORDS: Mie scattering, Scattering, Spectroscopy, Transmittance, Optical properties, Time resolved spectroscopy, Particles, Latex, Estimation theory, Laser scattering

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