A lens-less optical fiber designed for enhanced-fluorescence biosensor applications is presented. In order to obtain the enhanced sensor performances, two elements are essential: a planar antenna that redirects fluorescence emission into a narrow cone and an automated fiber-based optical system for multi-spot analysis. In particular, the potential early diagnosis of sepsis via C-reactive protein (CRP) detection is here demonstrated, reaching a limit of detection of 1.5 ng/mL), which is in the clinical range of interest for such biomarker. Upon the combination with other sepsis biomarkers, the presented sensor can become relevant for the early diagnosis of sepsis. These results validate the developed prototype as a simple, affordable, easy-to-operate, plug&play device with fast turnaround times, compatible with standardized micro-well arrays, and potentially suitable for POC applications with respect to the diagnosis of sepsis. It is also suitable for implementation with other biomarkers and liquid environments.
A major challenge in photonic quantum technologies is two-photon interference from distinct quantum emitters on the same chip. Here, we show and discuss recent results on Hong–Ou–Mandel interference experiments using couples of single organic molecules within few tens of microns, yielding post-selected visibilities of up to 97%. In particular, we discuss the potential interest for future realizations of measurement-device independent quantum key distribution protocols for information-theoretic secure communication.
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