Mr. Mahyar Osanlouy Profile

Mahyar Osanlouy

at Univ of Auckland

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Proceedings Article | 15 March 2019 Paper

Pulmonary lobar segmentation from computed tomography scans based on a statistical finite element analysis of lobe shape

Yuwen Zhang, Mahyar Osanlouy, Alys Clark, Hari Kumar, Clair King, Margaret Wilsher, David Milne, Eric Hoffman, Merryn Tawhai

Proceedings Volume 10949, 1094932 (2019) https://doi.org/10.1117/12.2512642

KEYWORDS: Lung, Image segmentation, Computed tomography, Shape analysis, Finite element methods, Statistical modeling, Principal component analysis, Tissues, Statistical analysis, Blood vessels

Read Abstract +

Automatic identification of pulmonary lobes from imaging is important in disease assessment and treatment planning. However, the lobar fissures can be difficult to detect automatically, as they are thin, usually of fuzzy appearance and incomplete on CT scans. The fissures can also be obscured by or confused with features of disease, for example the tissue abnormalities that characterise fibrosis. Traditional anatomical knowledge-based methods rely heavily on anatomic knowledge and largely ignore individual variability, which may result in failure to segment pathological lungs. In this study, we aim to overcome difficulties in identifying pulmonary fissures by using a statistical finite element shape model of lobes to guide lobar segmentation. By deforming a principle component analysis based statistical shape model onto an individual’s lung shape, we predict the likely region of fissure locations, to initialize the search region for fissures. Then, an eigenvalue of Hessian matrix analysis and a connected component eigenvector based analysis are used to determine a set of fissure-like candidate points. A smooth multi-level β-spline curve is fitted to the most fissure-like points (those with high fissure probability) and the fitted fissure plane is extrapolated to the lung boundaries. The method was tested on 20 inspiratory and expiratory CT scans, and the results show that the algorithm performs well both in healthy young subjects and older subjects with fibrosis. The method was able to estimate the fissure location in 100% of cases, whereas two comparison segmentation softwares that use anatomy-based methods were unable to segment 7/20 and 9/20 subjects, respectively.

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