Ms. Lúcia Mara Januário Anjos Profile

Lúcia Mara Januário Anjos

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Proceedings Article | 5 March 2015 Paper

Low-intensity infrared laser effects on zymosan-induced articular inflammatory response

Lúcia Mara Januário dos Anjos, Adenilson da Fonseca, Jacy Gameiro, Flávia de Paoli

Proceedings Volume 9321, 932114 (2015) https://doi.org/10.1117/12.2079785

KEYWORDS: Laser therapeutics, Cell death, Infrared lasers, Cartilage, Low-intensity laser therapy, Connective tissue, Tissues, Beam controllers, Morphological analysis, Phototherapy

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Low-level therapy laser is a phototherapy treatment that involves the application of low power light in the red or infrared wavelengths in various diseases such as arthritis. In this work, we investigated whether low-intensity infrared laser therapy could cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosaninduced articular inflammatory process. Inflammatory process was induced in C57BL/6 mouse by intra-articular injection of zymosan into rear tibio-tarsal joints. Thirty animals were divided in five groups: (I) control, (II) laser, (III) zymosan-induced, (IV) zymosan-induced + laser and (V). Laser exposure was performed after zymosan administration with low-intensity infrared laser (830 nm), power 10 mW, fluence 3.0 J/cm² at continuous mode emission, in five doses. Twenty-four hours after last irradiation, the animals were sacrificed and the right joints fixed and demineralized. Morphological analysis was observed by hematoxylin and eosin stain, pro-apoptotic (caspase-6) was analyzed by immunocytochemistry and DNA fragmentation was performed by TUNEL assay in articular cartilage cells. Inflammatory process was observed in connective tissue near to articular cartilage, in IV and V groups, indicating zymosan effect. This process was decreased in both groups after laser treatment and dexamethasone. Although groups III and IV presented higher caspase-6 and DNA fragmentation percentages, statistical differences were not observed when compared to groups I and II. Our results suggest that therapies based on low-intensity infrared lasers could reduce inflammatory process and could not cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosan-induced articular inflammatory process.

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