Dr. Liang Hong Profile

Dr. Liang Hong

at Shenzhen Univ

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Proceedings Article | 15 November 2018 Paper

Low-energy IR780 nanoemulsion for photodynamic therapy

Liang Hong, Jia Zhang, Li-Wei Liu, Jun-Le Qu

Proceedings Volume 10964, 109646C (2018) https://doi.org/10.1117/12.2506523

KEYWORDS: Absorption, Photodynamic therapy, Neon, Electroluminescence, Near infrared, Statistical analysis, Dynamic light scattering, Nanoparticles, Chemical analysis, Visualization

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As a near-infrared photosensitizer, IR780 is a promising agent for photodynamic therapy. However, its clinical application was limited by its poor aqueous solubility and chemical stability. Therefore, the purpose of this study was to prepare IR780 encapsulated nanoemulsion (IR780-NE) to enhance the solubility and chemical stability of IR780, using a low-energy emulsion inversion point (EIP) method, which could avoid complex procedure and IR780 degradation during preparation process. The IR780-NE presented a homogeneous and clear appearance, as well as a mean droplet diameter of 38.17 ± 3.59 nm, as determined by dynamic light scattering. The IR780-NE greatly enhanced the chemical stability of IR780, with more than 80% IR780 retained after storage at 25 °C for 4 days. The IR780-NE also showed satisfactory physical stability, with no alteration of mean droplet diameter during storage at 25 °C for 4 days or 4 °C for 30 days. The zeta potential of the IR780-NE was nearly zero (-0.27 ± 2.06 mV), and the ultraviolet-visible light absorption spectrum showed that the near-infrared light absorbing ability of IR780 was not influenced. In conclusion, the IR780-NE is a potential delivery system for the application of IR780 in biological systems.

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