Mr. Jesse Lohela Profile

Jesse Lohela

at Univ of Oulu

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Publications (3)

Proceedings Article | 27 November 2023 Paper

Tissue optical clearing for fNIRS studies in radiotherapy

Ekaterina Lazareva, Priya Karthikeyan, Jesse Lohela, Kalle Inget, Vesa Korhonen, Sakari Karhula, Juha Nikkinen, Valery Tuchin, Teemu Myllyla

Proceedings Volume 12770, 1277014 (2023) https://doi.org/10.1117/12.2687657

KEYWORDS: Radiotherapy, Tissues, Optical clearing, Absorbance, Brain, X-rays, Skin, Light sources, Brain tissue, Spectroscopy

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SPIE Journal Paper | 31 January 2023 Open Access

Cerebral tissue oxygenation response to brain irradiation measured during clinical radiotherapy

Teemu Myllylä, Vesa Korhonen, Priya Karthikeyan, Ulriika Honka, Jesse Lohela, Kalle Inget, Hany Ferdinando, Sakari Karhula, Juha Nikkinen

JBO, Vol. 28, Issue 01, 015002, (January 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.1.015002

KEYWORDS: Radiotherapy, Oxygenation, Brain, Tumors, Hemodynamics, Brain tissue, Tissues, Near infrared spectroscopy, Head, Hypoxia

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SignificanceCancer therapy treatments produce extensive changes in the physiological and morphological properties of tissues, which are also individual dependent. Currently, a key challenge involves developing more tailored cancer therapy, and consequently, individual biological response measurement during therapy, such as tumor hypoxia, is of high interest. This is the first time human cerebral haemodynamics and cerebral tissue oxygenation index (TOI) changes were measured during the irradiation in clinical radiotherapy and functional near-infrared spectroscopy (fNIRS) technique was demonstrated as a feasible technique for clinical use in radiotherapy, based on 34 online patient measurements.AimOur aim is to develop predictive biomarkers and noninvasive real-time methods to establish the effect of radiotherapy during treatment as well as to optimize radiotherapy dose planning for individual patients. In particular, fNIRS-based technique could offer an effective and clinically feasible online technique for continuous monitoring of brain tissue hypoxia and responses to chemo- and radiotherapy, which involves modulating tumor oxygenation to increase or decrease tumor hypoxia. We aim to show that fNIRS is feasible for repeatability measuring in patient radiotherapy, the temporal alterations of tissue oxygenation induced by radiation.ApproachFiber optics setup using multiwavelength fNIRS was built and combined with a medical linear accelerator to measure cerebral tissue oxygenation changes during the whole-brain radiotherapy treatment, where the radiation dose is given in whole brain area only preventing dosage to eyes. Correlation of temporal alterations in cerebral haemodynamics and TOI response to brain irradiation was quantified.ResultsOnline fNIRS patient measurement of cerebral haemodynamics during clinical brain radiotherapy is feasible in clinical environment, and results based on 34 patient measurements show strong temporal alterations in cerebral haemodynamics and decrease in TOI during brain irradiation and confirmed the repeatability. Our proof-of-concept study shows evidently that irradiation causes characteristic immediate changes in brain tissue oxygenation.ConclusionsIn particular, TOI seems to be a sensitive parameter to observe the tissue effects of radiotherapy. Monitoring the real-time interactions between the subjected radiation dose and corresponding haemodynamic effects may provide important tool for the researchers and clinicians in the field of radiotherapy. Eventually, presented fNIRS technique could be used for improving dose planning and safety control for individual patients.

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Proceedings Article | 29 April 2022 Paper

NIR spectroscopic immediate effects of irradiation on skin tissue: a comparison study of in vivo and ex vivo

Priya Karthikeyan, Ulriika Honka, Hany Ferdinando, Jesse Lohela, Kalle Inget, Vesa Korhonen, Sakari Karhula, Juha Nikkinen, Teemu Myllylä

Proceedings Volume 12192, 121920Q (2022) https://doi.org/10.1117/12.2626362

KEYWORDS: Skin, Radiotherapy, Tissues, In vivo imaging, Spectroscopy, Near infrared, Tissue optics, Absorbance

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