Mr. Jesse N. Fine Profile

Jesse N. Fine

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Publications (6)

SPIE Journal Paper | 18 November 2022 Open Access

Geometry design for a fully insertable glucose biosensor with multimodal optical readout

Jesse Fine, Gerard Coté, Michael McShane

JBO, Vol. 27, Issue 11, 117001, (November 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.11.117001

KEYWORDS: Biosensors, Glucose, Design and modelling, Oxygen, Diffusion, Simulations, Phosphorescence, Biological research, Tissue optics, Modeling

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SPIE Journal Paper | 3 May 2022 Open Access

Monte Carlo method for assessment of a multimodal insertable biosensor

Jesse Fine, Michael McShane, Gerard L. Coté

JBO, Vol. 27, Issue 08, 083017, (May 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.083017

KEYWORDS: Monte Carlo methods, Biosensors, Tissue optics, Fluorescence resonance energy transfer, Luminescence, Glucose, Phosphorescence, Absorption, Skin, Visible radiation

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SPIE Journal Paper | 29 March 2022 Open Access

Skin optical properties in the obese and their relation to body mass index: a review

Andres Rodriguez, Mel Tananant Boonya-Ananta, Mariacarla Gonzalez, Vinh Nguyen Du Le, Jesse Fine, Cristina Palacios, Mike McShane, Gerard Coté, Jessica Ramella-Roman

JBO, Vol. 27, Issue 03, 030902, (March 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.3.030902

KEYWORDS: Skin, Collagen, Scattering, Absorption, Tissues, Optical properties, Brain-machine interfaces, Blood, Water, Capillaries

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Significance: Obesity is a worldwide epidemic contributing directly to several cardiovascular risk factors including hypertension and type 2 diabetes. Wearable devices are becoming better at quantifying biomarkers relevant for the management of health and fitness. Unfortunately, both anecdotal evidence and recent studies indicate that some wearables have higher levels of error when utilized by populations with darker skin tones and high body mass index (BMI). There is an urgent need for a better evaluation of the limits of wearable health technologies when used by obese individuals. Aims: (1) To review the current know-how on changes due to obesity in the skin epidermis, dermis, and subcutis that could affect the skin optical properties; (2) for the green wavelength range, to evaluate the difference in absorption and scattering coefficients from the abdominal skin between individuals with and without elevated BMI. The changes include alterations in layer thickness and cell size, as well as significant differences in chromophores and scatterer content, e.g., water, hemoglobin, collagen, and lipids. Approach: We have summarized literature pertaining to changes in skin and its components in obesity and report the results of our search using articles published between years 1971 and 2020. A linear model was used to demonstrate the absorption and reduced scattering coefficient of the abdominal skin of individuals with and without elevated BMI in the green wavelength range (530 to 550 nm) that is typically found in most wearables. Results: The general trends indicate a decrease in absorption for both dermis and subcutis and an increase in reduced scattering for both epidermis and dermis. At 544-nm wavelength, a typical wavelength used for photoplethysmography (PPG), the absorption coefficient’s relative percentage difference between high and low BMI skin, was 49% in the subcutis, 19% in the dermis, and negligible in the epidermis, whereas the reduced scattering coefficient relative difference was 21%, 29%, and 165% respectively. Conclusions: These findings suggest that there could be significant errors in the output of optical devices used for monitoring health and fitness if changes due to obesity are not accounted for in their design.

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Proceedings Article | 2 March 2022 Presentation + Paper

An in vitro testing system for wrist-worn PPG devices

Erika Bodwell, Minh Nguyen, Jesse Fine, Kamryn Scott, Mike McShane, Gerard Coté

Proceedings Volume 11968, 1196808 (2022) https://doi.org/10.1117/12.2607969

KEYWORDS: Skin, Blood, Sensors, In vitro testing, Tissues, Tissue optics, Optical properties, Absorption, Arteries, Scattering

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Proceedings Article | 5 March 2021 Presentation + Paper

Design selection of a fully-implantable and optically-transduced glucose biosensor via Monte Carlo modeling

Jesse Fine, Mike McShane, Gerard Coté

Proceedings Volume 11651, 116510U (2021) https://doi.org/10.1117/12.2577737

KEYWORDS: Monte Carlo methods, Biosensors, Glucose, Optimization (mathematics), Skin, Instrument modeling, Blood, Tissue optics, Stochastic processes, Scattering

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Proceedings Article | 14 February 2020 Presentation + Paper

Parallelized multi-layered Monte Carlo model for evaluation of a proximal phalanx photoplethysmograph

Jesse Fine, Tananant Boonya-ananta, Andres Rodriguez, Jessica Ramella-Roman, Mike McShane, Gerard Cote

Proceedings Volume 11247, 1124702 (2020) https://doi.org/10.1117/12.2543590

KEYWORDS: Arteries, Skin, Monte Carlo methods, Blood pressure, Tissues, Tissue optics, Photoplethysmography, Optical properties, Photon transport

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