In this work, we investigate the changes of microviscosity in cancer cells exposed to chemotherapy with cisplatin and oxaliplatin. We analyzed the plasma membrane viscosity using fluorescent molecular rotor and fluorescence lifetime imaging. Our results in vitro show a significant increase in viscosity after treatment, which correlated with membrane lipid composition. The obtained data indicate the involvement of plasma membrane in the mechanisms of the platinum drug action.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.