We present a multifunctional tethered capsule endomicroscopy (TCE) system for surveillance and potential treatment of the upper gastrointestinal (GI) tract. The system integrates dual-wavelength OCT imaging operating at 800 nm and 1300 nm, an ultracompact endoscope camera, and an ablation laser. The dual-wavelength OCT enables ultrahigh-resolution imaging of superficial layers (800 nm) as well as deep tissue layers (1300 nm), while the miniature camera provides real-time visualization of the OCT imaged and laser ablation area. The multifunctional imaging and ablation capability of the capsule was demonstrated in vivo on swine models. By combining these functions in a single device, the system offers an effective solution for endoscopic screening, diagnosis, and potential ablation treatment in the GI tract.
This study reports the results of our recent in vivo study using attenuation-based quantitative OCT for intra-operative mapping of brain cancer in patients. A total of 34 brain cancer patients were recruited, and an optimal optical attenuation threshold of 4.3 mm-1 was established with cancer of lower values. We achieved an excellent specificity of over 98%, with a corresponding sensitivity of over 95% for both high-grade and low-grade cancers. Applying the established optical attenuation threshold to infiltrated tissues, we were able to identify regions of cancers qualitatively matching the neuropathologist’s assessment. The study suggests that optical attenuation-based quantitative OCT represents a promising technology for intraoperative brain cancer detection and
The feasibility of ultrahigh-resolution OCT capsule endoscopy working at 800 nm was demonstrated by imaging ex vivo freshly resected human esophageal tissues, and its performance was compared with conventional volumetric laser endomicroscopy (VLE) working at 1300 nm. The results showed that the ultrahigh-resolution capsule can identify histology-confirmed diagnostic features with much finer details and contrast, particularly in mucosal layers, and demonstrated its promising potential of differentiating pathological changes in earlier stages.
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