A compacted random laser with a triple optical cavity is designed by directly coupling the compound between three cavities: the fundamental, ring, and external cavities. The laser action in this counterintuitive cavity is enabled by feedback from strong reflections on the inner and external surfaces, as well as scattering centers silver nanowires. This unique property of the triple optical cavity results in a lower laser threshold and enhanced emission spectra. These results provide up new possibilities for designing devices integrated and miniature technology.
Apart from the huge physiological importance of hemo-, myo- globin and hemin, they play also an important role as robust and effective recognition agents in chemical and biological sensors. In this aspect the key factor in developing a reliable biosensor is the immobilization on the transducer. Usually immobilization can be produced by chemical methods, but there is frequently a need for homogeneous films of well-controlled thickness or films which can be deposited in a dry environment. The film thickness is of main importance for the optical transducer detected by Surface Plasmon Resonance (SPR) what is used in our study. Hundreds of immobilization protocols have been developed in an effort to ensure high performance sensing. All of them are focused on finding and deposition of appropriate matrices in which the recognition medium can be incorporated. However, the matrix always deteriorates the effectiveness of recognition. It seems that the best approach is to perform direct immobilization of the recognition medium. However, this is not always possible regarding the organic materials – the problem is whether the deposition retains the bioactivity of the recognition agent. On the other hand, the type of the transducer also imposes constrains. For example, the direct immobilization of the proteins is not possible for electrochemical sensors, because of the distance between the redox center and electrodes is too long. Evaluating the pros and cons of organic (protein) film deposition we have considered to study the possibility for direct immobilization of myoglobin, hemoglobin and hemin on SPR transducer. To best of our knowledge, SPR biochip with immobilized myoglobin, hemoglobin and hemin has never been constructed before. We have used spin coating, for direct immobilization and matrix-assisted pulsed-laser evaporation (MAPLE) for elaboration of the SPR biochip. The performance of both SPR chips – direct and MAPLE immobilized, was studied by SPR registration of the binding activity of myo- and hemo- globin ligands with carbon monoxide (CO), carbon dioxide (CO2) and nitride oxide (NO).
Random lasers are a novel disorder-based laser light source with many photonics applications. In the present work we study the optical properties of a new unordered medium consisted of an epoxy resin as matrix with dissolved different binary solutions of Rhodamine 6G and Rhodamine B. The choice of these dyes is related to their great application in laser physics. A detailed study of the spectral dependence of fluorescence is performed. The spontaneous emission is very intensive and follows the spectral dependence of dyes transmission and exceeds 750 nm. The threshold of the laser medium is 1.6 mJ for 10 ns pulse at second harmonics of Nd:YAG laser, and full width at half maximum (FWHM) is around 1.5 nm. Slope efficiency of the medium is 16%. The laser generation without resonator was studied also and lasing emission at 597 nm was observed. The fact can be explained by random lasing provided by the medium. This is in good relation and in accordance with the intensive scattering inherent to the medium which is registered. Not used additional scatter centers such as ZnO nanorods or Ag, Al, Al2O3, TiO2 agglomerates and others in our experiments.
By using the developed by us approaches and instrumentation, we have obtained and presented series of systematized
data, which are important for the use of the laser light in infrared (IR) spectral region. The obtained data include: 1) reflectivity of the human tooth dentin; 2) the spatial intensity distribution in the cross-section of the light beam penetrating the tooth’s dentin; 3) the absorbed and the diffused parts of the laser light that have been determined separately through combination of optical and calorimetric techniques. The last result is the most important because it permits to calculate the dentin absorption and scattering coefficients. The study is performed for the laser light at two
easily generated wavelengths – 1.06 μm and 1.36 μm, emitted by the Nd:YAG laser that is well known, commercially
available, economical and widely used in many laboratories and medical institutions. The study is made on the basis of
fresh in-vitro teeth samples from the persons of Bulgaria, Sofia region.
On the base of our previous experience in the dual-color lasers we present our actual development - experimental realization, theory of a flash-lamp pumped Nd3+:YAG laser, that produces output at two desired (tunable) lines in the spectral range of 1μm -1.44 μm in free lasing and Q-switching operation. The laser operation avoids the wave’s competition effect for the two generations operating in two different parts of the active volume of an active single crystal and two closely disposed prism-selected resonators. Also, as we have shown, varying the partial laser volumes and the losses at each resonator in combination, it is possible to produce the generation at the two desired wavelengths with near equal output energy, peak power simultaneously or at desired time interval. We have found and treated some peculiarity of the formation of the generation, such as the actually used parts of the partial volumes.
In the recent decade the applications of photodynamic therapy (PDT) rapidly increase in several topics and one of
areas where the PDT in the future will be play significant role is dentistry. The different photosensitizing complexes
with a good water solubility and with absorption with an intensive maximum in the red region (630-690 nm), which
makes them suitable for photodynamic treatments, were investigated. The photochemical properties of complexes for
singlet oxygen generation were investigated and were shown relations between uptake levels and light intensity to
achieve increase in photodynamic efficacy. Photodynamic efficacy against fungi Candida albicans and bacteria's E.
faecalis, MRSA and S. Mutans in planktonic media was evaluated. The high photodynamic efficacy was shown for
SiPc at very low concentrations (0.9 μM) and light doses of 50 J cm-2 by intensity of light 60 mW cm-2. The
photodynamic response for E. faecalis, MRSA and S. Mutans, after treatments with different photosensitizers show
strong dependence on concentrations of photsensitzers and micro organisms. The level of inactivation of the pathogen
bacteria's from 1-2 degree of initial concentration up to full inactivation was observed. The studied complexes were
compared to the recently studied Methylene blue, Haematoporphyrine and tetra-methylpirydiloxy Zn(II)-
phthalocyanines and experimental results show that some of them have a good potential for inactivation of
representative pathogenic bacterial strains.
Experimental results also indicate that photodynamic therapy appears an effective method for inactivation of oral
pathogenic bacterias and fungi.
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