Dr. Fred Kashefi Profile

Dr. Fred Kashefi

Assistant Professor at Khavaran Higher Education Institute

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Proceedings Article | 23 March 2007 Paper

Obstructive sleep apnea screening by NIRS imaging

Feraydune Kashefi, Donald Watenpaugh, Hanli Liu

Proceedings Volume 6424, 64242H (2007) https://doi.org/10.1117/12.702239

KEYWORDS: Near infrared spectroscopy, Brain, Control systems, Hemodynamics, Tissues, Oxygen, Sensors, Light emitting diodes, Molecules, Data acquisition

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This study aimed at determining cerebral hemodynamic parameters in human subjects during breath holding using near infrared spectroscopy (NIRS). Breath holding serves as a method of simulation OSA (Obstructive Sleep Apnea). Data was acquired non-invasively from 40 subjects, twenty OSA sufferers (10 females, 10 males, age 20-70 years), and twenty normal volunteers (10 females, 10 males, age 20-65 years). Measurements were conducted using a LED Imager (LEDI) during breath holding. In comparing OSA subjects with controls during breath holding, a consistent increase or even a decrease in oxy- ([O₂Hb]), deoxy- ([HHb]), total hemoglobin ([tHb]) concentrations, and tissue hemoglobin oxygen saturation (SO₂) in the regional brain tissue were observed. The LEDI probe consists of 4 sources and 10 detectors serving as 4 sets of 1 source and 4 detectors each. A three wavelength (730, 805, and 850 nm) LED was used and the wavelengths were switched sequentially. The distance between sources and the source-detector separation were 2.5 cm. Data acquisition consisted of three segments, baseline for one minute, followed by a period of breath holding, and then 2 minutes of recovery time. The duration of the breath holding was subject-dependent. Our investigation proves that NIR spectroscopy could be used as a tool for detecting cerebral hemodynamics and also serves as a method of screening patients with OSA.

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