The reactivity of skin microcirculation was compared in 3 groups of patients. Group 1 included healthy volunteers without cardiovascular diseases (n = 19), Group 2 included patients with diseases that increase the risk of cardiovascular events (arterial hypertension and / or angina pectoris and / or diabetes mellitus) (n = 40), Group 3 included patients with a history of cardiovascular events (myocardial infarction and / or stroke and / or coronary revascularization) (n = 20). Microcirculation measurement was performed by Laser Doppler flowmetry using LAKK 02 device during the heating test. Patients from Group 2 had a decrease in the reactivity of skin microcirculation compared with the control group, while the reactivity of skin microcirculation in these patients was better than in patients from Group 3. The highest difference was observed for the Slope_180 parameter (slope of the regression line of the microcirculation curve for the first 180 seconds of heating). Using the machine learning we developed a method for classifying patients into Group 1, Group 2, Group 3 according to the Slope_180 parameter. The sensitivity and specificity of Slope_180 parameter in identifying patients with cardiovascular diseases, diabetes (groups 2 and 3 together) was 82% and 68%, respectively. Such methods may be a promising for health screening. Thus, the relationship between the severity of skin microcirculation disorders and the “severity” of cardiovascular disease demonstrates the prospect of studying microcirculatory disorders as a cardiovascular risk factor.
Minimal erythema dose (MED) is the amount of ultraviolet (UV) radiation needed to induce a mild skin erythema reaction after 24 hours following exposure. Determination of MED is based on the assessment of UV-erythema and traditionally performed visually by naked eye, which is subjective and connected with errors due to high intrarater and interrater variability. The application of non-invasive and quantitative techniques such as optical methods could improve MED calculation, allowing us to detect and quantify alterations in epidermis and dermis induced by UV irradiation. In the current study the analysis of microcirculation parameters by non-invasive optical methods revealed the relationship between the oxygen consumption and a dose of UV radiation. Results also showed the correlation of oxygen consumption of UV-exposed tissues normalized to intact skin with a dose of UV. Moreover, we described tendencies in dynamics of porphyrin fluorescence intensity at different time points after UV-exposure. Optical methods have some prospects in non-invasive and predictive evaluation of UV erythema and MED and more research should be conducted in this field.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.