In this paper, a concave carbon-based polymer nanocomposite film was developed for high-amplitude focused ultrasound. The composite films consisting of candle soot nanoparticles (CSNPs) and elastomeric polymers were used as the high-frequency optoacoustic sources. To generated focused ultrasound, these composite films were formed on concave optical lens. A focal waveform with peak to peak pressure of ~45 MPa was achieved at the focal point. The prototyped laser-induced focused ultrasound (LIFU) was applied with noninvasive sonothrombolysis in vitro. For enhanced cavitation effect, we demonstrated a spatio-temporal superposition approach of LIFU treatment in conjunction with low-frequency focused ultrasound from a piezoelectric ultrasound transducer. The in vitro results showed that dualfrequency excitation ultrasound treatment can achieve the sonothrombolysis efficiency of approximately 28% in half of an hour (2 mg/min), suggesting that LIFU generated from composite films may be promising in precision sonothrombolysis.
In this work, a magneto-acousto-electrial tomography (MAET) method based on laser-generated ultrasound excitation was proposed for high-spatial-resolution images of the impedance of conductive media. Optically generated ultrasound is reported with broad bandwidth and insensitive to electromagnetic interference (EMI). Composite films were used as the optoacoustic sources, which composed of candle soot (CS) and elastomeric polymers. To characterize the laser-generated ultrasonic waves, laser Doppler vibrometer was adopted as the detecting device making the system totally optical while maintaining millimeter-level resolution and detective depths of several centimeter. Photoacoustic waves were then introduced to a sample of different conductivity distribution by laser-generated ultrasound transmitter at one point and detected by a pair of electrodes on the surface of the sample. Due to the absence of EMI between acoustic excitation and magnetic field, the combination of non-electronic ultrasound generator and low-cost, non-invasive MAET have shown its great capacity for effective early tumor assessment.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.