Dr. David Christopher O. Pickard Profile

Dr. David Christopher O. Pickard

at Univ College London

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Author

Publications (10)

SPIE Journal Paper | 1 November 2004 Open Access

Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast

Kristie Johnson, Dennis Chicken, David Pickard, Andrew Lee, Gavin Briggs, Mary Falzon, Irving Bigio, Mohammed Keshtgar, Stephen Bown

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1802191

KEYWORDS: Cancer, Lymphatic system, Spectroscopy, Scattering, Tissue optics, Cell biology, Breast cancer, Tissues, Diagnostics, Lamps

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Proceedings Article | 8 October 2003 Paper

Elastic scattering spectroscopy in the diagnosis of pigmented lesions: comparison with clinical and histopathological diagnosis

J. Scarisbrick, C. Pickard, Andrew Lee, Gavin Briggs, Kristie Johnson, Stephen Bown, Marco Novelli, M. Keshtgar, Irving Bigio, R. Yu

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.501181

KEYWORDS: Melanoma, Scattering, Diagnostics, Biopsy, Tissues, Light scattering, Spectroscopy, Skin, Absorption, Reflectivity

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Successful management of malignant melanoma depends on early detection and diagnostic accuracy. However studies have found a diagnostic accuracy of malignant melanoma amongst dermatologists of only 80% compared with histological diagnosis, results are generally poorer with family practitioners and dermatology trainees. Elastic scattering spectroscopy (ESS) is a non-invasive procedure that utilises elastically scattered light. A related technique, reflectance spectrometry, may discriminate between benign and malignant pigmented lesions in vivo. Objectives: We have therefore assessed an ESS biopsy system in the diagnosis of melanocytic lesions in vivo and compared the results to both clinical and histopathological diagnosis. Patients/Methods: One hundred melanocytic lesions from 77 patients attending our pigmented lesion clinic between 1999 and 2001 or seen at our Melanoma Day were examined clinically and divided into benign, dysplastic or malignant lesions. ESS spectra were acquired at several points from each lesion and adjacent normal skin. Lesions were then excised and sent for histological examination. Results: Lesions were histologically classified as 12 malignant melanoma (3 in-situ), 14 dysplastic naevi and 57 benign naevi (a further 17 clinically benign naevi were included which were not selected for excision). Clinical examination had a sensitivity of 75% and specificity of 91% for detection of malignant melanoma from other melanocytic lesions and overall diagnostic accuracy of differentiating melanocytic lesions of 71%. ESS spectral diagnosis classified by linear discriminant analysis indicated a sensitivity of 84% and specificity of 65% for detection of malignant melanoma from other melanocytic lesions. However the ESS spectral diagnosis included several readings per lesion and clinically this is not relevant. Therefore an ESS per lesional diagnosis was taken as the most aggressive diagnosis. This had a sensitivity of 100% and specificity of 75% for detection of malignant melanoma from other melanocytic lesions and overall diagnostic accuracy of differentiating melanocytic lesions of 69%. Discussion: These data suggest that ESS may be capable of differentiating malignant melanoma, dysplastic and benign naevi with a high sensitivity and provide adjuvant information to clinical examination by a dermatologist, which could be useful in the triage of melanocytic lesions.

Proceedings Article | 1 May 2002 Paper

Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus

David Pickard, Irving Bigio, Stephen Bown, Laurence Lovat, Paul Ripley, Marco Novelli

Proceedings Volume 4613, (2002) https://doi.org/10.1117/12.465250

KEYWORDS: Biopsy, Tissue optics, Spectroscopy, Tissues, Endoscopy, Scattering, Cancer, Absorption, Diagnostics, Endoscopes

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Proceedings Article | 31 October 2001 Paper

Optical biopsy for the diagnosis of breast tumors

David Pickard, Irving Bigio, Stephen Bown, Gavin Briggs, Andrew Lee, Paul Ripley, Sunil Lakhani

Proceedings Volume 4432, (2001) https://doi.org/10.1117/12.447131

KEYWORDS: Biopsy, Tissues, Breast, Tissue optics, Spectroscopy, Cancer, Lymphatic system, Scattering, Surgery, Diagnostics

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Proceedings Article | 31 October 2001 Paper

Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus

David Pickard, Irving Bigio, Stephen Bown, Laurence Lovat, Paul Ripley, Marco Novelli

Proceedings Volume 4432, (2001) https://doi.org/10.1117/12.447133

KEYWORDS: Tissue optics, Biopsy, Tissues, Spectroscopy, Scattering, Diagnostics, Endoscopy, Endoscopes, Light scattering, Absorption

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Proceedings Article | 26 October 2001 Paper

Interstitial laser photocoagulation of breast tumors

David Pickard, Stephen Bown, Gavin Briggs, Margret Hall-Craggs

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446500

KEYWORDS: Breast, Ultrasonography, Laser coagulation, Semiconductor lasers, Surgery, Laser tissue interaction, Laser therapeutics, Tumors, Solids, Tissue optics

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Proceedings Article | 16 November 2000 Paper

Diagnosis of dysplasia in Barrett's oesophagus with in-situ elastic-scattering spectroscopy

David Pickard, Laurence Lovat, Marco Novelli, Paul Ripley, Christine Kelly, Irving Bigio, Stephen Bown

Proceedings Volume 4161, (2000) https://doi.org/10.1117/12.409320

KEYWORDS: Tissue optics, Biopsy, Spectroscopy, Tissues, Scattering, Diagnostics, Endoscopy, Light scattering, Endoscopes, Cancer

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Proceedings Article | 17 May 2000 Paper

Optical biopsy: in-vivo diagnosis of breast cancer using elastic scatter spectroscopy

David Pickard, Gavin Briggs, Christobel Saunders, Sunil Lakhani, Paul Ripley, Irving Bigio, Stephen Bown

Proceedings Volume 3907, (2000) https://doi.org/10.1117/12.386304

KEYWORDS: Tissues, Biopsy, Tissue optics, Breast, Spectroscopy, Scattering, Breast cancer, Absorption, Lymphatic system, In vivo imaging

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Proceedings Article | 19 April 2000 Paper

Elastic scattering spectroscopy in vivo: optical biopsies of cancers of the breast and GI tract

David Pickard, Gavin Briggs, Christobel Saunders, Sunil Lakhani, Paul Ripley, Irving Bigio, Stephen Bown

Proceedings Volume 3917, (2000) https://doi.org/10.1117/12.382717

KEYWORDS: Biopsy, Tissues, Tissue optics, Breast, Scattering, Spectroscopy, Breast cancer, Cancer, Absorption, Lymphatic system

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SPIE Journal Paper | 1 April 2000 Open Access

Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results

Irving Bigio, Stephen Bown, Gavin Briggs, Christine Kelley, Sunil Lakhani, David Pickard, Paul Ripley, Ian Rose, Christobel Saunders

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429990

KEYWORDS: Tissue optics, Tissues, Cancer, Surgery, Biopsy, Breast, Tumors, Breast cancer, Optical testing, Spectroscopy

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