Targeting at a low cost and accessible diagnostic device in clinical practice, a compact surface plasmon resonance (SPR) biosensor with a large dynamic range in high sensitivity is designed to satisfy commercial needs in food safety, environmental bio-pollution monitoring, and fast clinical diagnosis. The core component integrates an optical coupler, a sample-loading plate, and angle-tuning reflectors is injection-molded as a free-from prism made of plastic optics. This design makes a matching-oil-free operation during operation. The disposability of this low-cost component ensures testing or diagnosis without cross contamination in bio-samples.
For the purpose of point of care (POC), a disposable polymer-molding prism with two parabolic side surfaces is employed for the ultra compact SPRI biosensor. A compact SPRI biosensor downsized to a form factor of 20 cm *15 cm*5 cm with extremely high sensitivity and large dynamic range is proposed in this study. With the cost effective and disposable polymer-molding prism design, the cross contamination between samples can be avoided. In this demonstration, we integrated the CCD detection system and multichannel fluidic system into this device that allows users to quickly screen various samples simultaneously.
With the development of a point of care (POC) biosensor in mind, a polymer-molding prism with double parabolic
surfaces is invented and developed to implement an ultra-compact SPR biosensor with extremely high sensitivity. The
polymer molded parabolic prism is cost effective and disposable, thus cross contamination between biological samples
can be avoided. A highly sensitive biosensor with a form factor less than 15cm*15cm*5cm was received with a tunable
excitation angle of light beam for a large dynamic range. A highly sensitive optical phase interrogation was
demonstrated. The biosensor is also compatible to a modern microscopy platform.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.