High-density diffuse optical tomography (HD-DOT) has been shown to be a promising alternative to fMRI for mapping cortical hemodynamics in young healthy adults. HD-DOT imaging can be more precise when coupled with subject specific head models rather than generic atlas-based head models. While MRI-derived head models are commonly used, in some patient groups including subjects with metal and/or electrical implants, only CT images can be obtained. In this study, we developed a CT-based head modeling pipeline and demonstrated the feasibility of improved mapping of brain responses to tasks compared to a generic atlas-based head-model.
We developed a wearable HD-DOT instrument (WHD-DOT) that provides a safe and portable neuroimaging modality with enhanced image resolution and brain specificity. Our design replaces bulky fibers with smart electronic cylindrical source and detector modules that brush through hair and maintain stable optode-scalp coupling. Our current prototype has four independent WHD patches to create a system with 32 sources and 32 detectors at 13 mm optode spacing. Light level vs. distance curves confirm dynamic range and cross-talk specifications match fiber-based HD-DOT. We tested feasibility using retinotopic mapping of visual cortex. Optode location error between photometric measurements and MRI-based fiducials is <5mm.
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