PurposeWe aim to investigate the localization, visibility, and measurement of lung nodules in digital chest tomosynthesis (DTS).ApproachComputed tomography (CT), maximum intensity projections (CT-MIP) (transaxial versus coronal orientation), and computer-aided detection (CAD) were used as location reference, and inter- and intra-observer agreement regarding lung nodule size was assessed. Five radiologists analyzed DTS and CT images from 24 participants with lung nodules≥100 mm3, focusing on lung nodule localization, visibility, and measurement on DTS. Visual grading was used to compare if coronal or transaxial CT-MIP better facilitated the localization of lung nodules in DTS.ResultsThe majority of the lung nodules (79%) were rated as visible in DTS, although less clearly in comparison with CT. Coronal CT-MIP was the preferred orientation in the task of locating nodules on DTS. On DTS, area-based lung nodule size estimates resulted in significantly less measurement variability when compared with nodule size estimated based on mean diameter (mD) (p<0.05). Also, on DTS, area-based lung nodule size estimates were more accurate (SEE=38.7 mm3) than lung nodule size estimates based on mean diameter (SEE=42.7 mm3).ConclusionsCoronal CT-MIP images are superior to transaxial CT-MIP images in facilitating lung nodule localization in DTS. Most nodules≥100 mm3 found on CT can be visualized, correctly localized, and measured in DTS, and area-based measurement may be the key to more precise and less variable nodule measurements on DTS.
PurposeChest tomosynthesis (CTS) has a relatively longer acquisition time compared with chest X-ray, which may increase the risk of motion artifacts in the reconstructed images. Motion artifacts induced by breathing motion adversely impact the image quality. This study aims to reduce these artifacts by excluding projection images identified with breathing motion prior to the reconstruction of section images and to assess if motion compensation improves overall image quality.ApproachIn this study, 2969 CTS examinations were analyzed to identify examinations where breathing motion has occurred using a method based on localizing the diaphragm border in each of the projection images. A trajectory over diaphragm positions was estimated from a second-order polynomial curve fit, and projection images where the diaphragm border deviated from the trajectory were removed before reconstruction. The image quality between motion-compensated and uncompensated examinations was evaluated using the image quality criteria for anatomical structures and image artifacts in a visual grading characteristic (VGC) study. The resulting rating data were statistically analyzed using the software VGC analyzer.ResultsA total of 58 examinations were included in this study with breathing motion occurring either at the beginning or end (n=17) or throughout the entire acquisition (n=41). In general, no significant difference in image quality or presence of motion artifacts was shown between the motion-compensated and uncompensated examinations. However, motion compensation significantly improved the image quality and reduced the motion artifacts in cases where motion occurred at the beginning or end. In examinations where motion occurred throughout the acquisition, motion compensation led to a significant increase in ripple artifacts and noise.ConclusionsCompensation for respiratory motion in CTS by excluding projection images may improve the image quality if the motion occurs mainly at the beginning or end of the examination. However, the disadvantages of excluding projections may outweigh the benefits of motion compensation.
KEYWORDS: Chest, Radiology, Radiography, Monte Carlo methods, Medical imaging, Optical spheres, Chest imaging, Statistical analysis, Sensors, Software development
Chest tomosynthesis may be a suitable alternative to computed tomography for the clinical task of follow up of pulmonary nodules. The aim of the present study was to investigate the detection of pulmonary nodule growth suggestive of malignancy using chest tomosynthesis. Previous studies have indicated remained levels of detection of pulmonary nodules at dose levels corresponding to that of a conventional lateral radiograph, approximately 0.04 mSv, which motivated to perform the present study this dose level. Pairs of chest tomosynthesis image sets, where the image sets in each pair were acquired of the same patient at two separate occasions, were included in the study. Simulated nodules with original diameters of approximately 8 mm were inserted in the pairs of image sets, simulating situations where the nodule had remained stable in size or increased isotropically in size between the two different imaging occasions. Four different categories of nodule growth were included, corresponding to a volume increase of approximately 21 %, 68 %, 108 % and 250 %. All nodules were centered in the depth direction in the tomosynthesis images. All images were subjected to a simulated dose reduction, resulting in images corresponding to an effective dose of 0.04 mSv. Four observers were given the task of rating their confidence that the nodule was stable in size or not on a five-level rating scale. This was done both before any size measurements were made of the nodule as well as after measurements were performed. Using Receiver operating characteristic analysis, the rating data for the nodules that were stable in size was compared to the rating data for the nodules simulated to have increased in size. Statistically significant differences between the rating distributions for the stable nodules and all of the four nodule growth categories were found. For the three largest nodule growths, nearly perfect detection of nodule growth was seen. In conclusion, the present study indicates that during optimal imaging conditions and for nodules with diameters of approximately 8 mm that grow fairly symmetrically, chest tomosynthesis performed at a dose level corresponding to that of a lateral chest radiograph can, with high sensitivity, differentiate nodules stable in size from nodules growing at rates associated with fast growing malignant nodules.
In chest tomosynthesis (TS) the most commonly used reconstruction methods are based on Filtered Back Projection (FBP) algorithms. Due to the limited angular range of x-ray projections, FBP reconstructed data is typically associated with a low spatial resolution in the out-of-plane dimension. Lung nodule measures that depend on depth information such as 3D shape and volume are therefore difficult to estimate. In this paper the relation between features from FBP reconstructed lung nodules and the true out-of-plane nodule elongation is investigated and a method for estimating the out-of-plane nodule elongation is proposed. In order to study these relations a number of steps that include simulation of spheroidal-shaped nodules, insertion into synthetic data volumes, construction of TS-projections and FBP-reconstruction were performed. In addition, the same procedure was used to simulate nodules and insert them into clinical chest TS projection data. The reconstructed nodule data was then investigated with respect to in-plane diameter, out-of-plane elongation, and attenuation coefficient. It was found that the voxel value in each nodule increased linearly with nodule elongation, for nodules with a constant attenuation coefficient. Similarly, the voxel value increased linearly with in-plane diameter. These observations indicate the possibility to predict the nodule elongation from the reconstructed voxel intensity values. Such a method would represent a quantitative approach to chest tomosynthesis that may be useful in future work on volume and growth rate estimation of lung nodules.
KEYWORDS: Fluoroscopy, Imaging systems, Stereoscopy, X-rays, 3D image processing, Image acquisition, 3D acquisition, Monte Carlo methods, Chest, X-ray imaging
Three-dimensional (3D) imaging with interventional fluoroscopy systems is today a common examination. The examination includes acquisition of two-dimensional projection images, used to reconstruct section images of the patient. The aim of the present study was to investigate the difference in resulting effective dose obtained using different levels of complexity in calculations of effective doses from these examinations. In the study the Siemens Artis Zeego interventional fluoroscopy system (Siemens Medical Solutions, Erlangen, Germany) was used. Images of anthropomorphic chest and pelvis phantoms were acquired. The exposure values obtained were used to calculate the resulting effective doses from the examinations, using the computer software PCXMC (STUK, Helsinki, Finland). The dose calculations were performed using three different methods: 1. using individual exposure values for each projection image, 2. using the mean tube voltage and the total DAP value, evenly distributed over the projection images, and 3. using the mean kV and the total DAP value, evenly distributed over smaller selection of projection images. The results revealed that the difference in resulting effective dose between the first two methods was smaller than 5%. When only a selection of projection images were used in the dose calculations the difference increased to over 10%. Given the uncertainties associated with the effective dose concept, the results indicate that dose calculations based on average exposure values distributed over a smaller selection of projection angles can provide reasonably accurate estimations of the radiation doses from 3D imaging using interventional fluoroscopy systems.
The primary aim of the present work was to analyze the effects of varying scatter-to-primary ratios on the appearance of
simulated nodules in chest tomosynthesis section images. Monte Carlo simulations of the chest tomosynthesis system
GE Definium 8000 VolumeRAD (GE Healthcare, Chalfont St. Giles, UK) were used to investigate the variation of
scatter-to-primary ratios between different angular projections. The simulations were based on a voxel phantom created
from CT images of an anthropomorphic chest phantom. An artificial nodule was inserted at 80 different positions in the
simulated phantom images, using five different approaches for the scatter-to-primary ratios in the insertion process. One
approach included individual determination of the scatter-to primary-ratio for each projection image and nodule location,
while the other four approaches were using mean value, median value and zero degree projection value of the scatter-toprimary
ratios at each nodule position as well as using a constant scatter-to-primary ratio of 0.5 for all nodule positions.
The results indicate that the scatter-to-primary ratios vary up to a factor of 10 between the different angular
tomosynthesis projections (±15°). However, the error in the resulting nodule contrast introduced by not taking all
variations into account is in general smaller than 10 %.
In chest tomosynthesis, low-dose projections collected over a limited angular range are used for reconstruction of section
images of the chest, resulting in a reduction of disturbing anatomy at a moderate increase in radiation dose compared to
chest radiography. In a previous study, we investigated the effects of learning with feedback on the detection of
pulmonary nodules in chest tomosynthesis. Six observers with varying degrees of experience of chest tomosynthesis
analyzed tomosynthesis cases for presence of pulmonary nodules. The cases were analyzed before and after learning with
feedback. Multidetector computed tomography (MDCT) was used as reference. The differences in performance between
the two readings were calculated using the jackknife alternative free-response receiver operating characteristics
(JAFROC-2) as primary measure of detectability. Significant differences between the readings were found only for
observers inexperienced in chest tomosynthesis. The purpose of the present study was to extend the statistical analysis of
the results of the previous study, including JAFROC-1 analysis and FROC curves in the analysis. The results are
consistent with the results of the previous study and, furthermore, JAFROC-1 gave lower p-values than JAFROC-2 for
the observers who improved their performance after learning with feedback.
Chest tomosynthesis has recently been introduced to healthcare as a low-dose alternative to CT or as a tool for improved
diagnostics in chest radiography with only a modest increase in radiation dose to the patient. However, no detailed
description of the dosimetry for this type of examination has been presented. The aim of this work was therefore to
investigate the dosimetry of chest tomosynthesis. The chest tomosynthesis examination was assumed to be performed
using a stationary detector and a vertically moving x-ray tube, exposing the patient from different angles. The Monte
Carlo based computer software PCXMC was used to determine the effective dose delivered to a standard-sized patient
from various angles using different assumptions of the distribution of the effective dose over the different projections.
The obtained conversion factors between input dose measures and effective dose for chest tomosynthesis for different
angular intervals were then compared with the horizontal projection. The results indicate that the error introduced by
using conversion factors for the PA projection in chest radiography for estimating the effective dose of chest
tomosynthesis is small for normally sized patients, especially if a conversion factor between KAP and effective dose is
used.
Chest tomosynthesis refers to the technique of collecting low-dose projections of the chest at different angles and using
these projections to reconstruct section images of the chest. In this study, a comparison of chest tomosynthesis and chest
radiography in the detection of pulmonary nodules was performed and the effect of clinical experience of chest
tomosynthesis was evaluated. Three senior thoracic radiologists, with more than ten years of experience of chest
radiology and 6 months of clinical experience of chest tomosynthesis, acted as observers in a jackknife free-response
receiver operating characteristics (JAFROC-1) study, performed on 42 patients with and 47 patients without pulmonary
nodules examined with both chest tomosynthesis and chest radiography. MDCT was used as reference and the total
number of nodules found using MDCT was 131. To investigate the effect of additional clinical experience of chest
tomosynthesis, a second reading session of the tomosynthesis images was performed one year after the initial one. The
JAFROC-1 figure of merit (FOM) was used as the principal measure of detectability. In comparison with chest
radiography, chest tomosynthesis performed significantly better with regard to detectability. The observer-averaged
JAFROC-1 FOM was 0.61 for tomosynthesis and 0.40 for radiography, giving a statistically significant difference
between the techniques of 0.21 (p<0.0001). The observer-averaged JAFROC-1 FOM of the second reading of the
tomosynthesis cases was not significantly higher than that of the first reading, indicating no improvement in detectability
due to additional clinical experience of tomosynthesis.
ViewDEX (Viewer for Digital Evaluation of X-ray images) is a Java-based DICOM-compatible software tool for
observer performance studies that can be used to display medical images with simultaneous registration of the observer's
response. The current release, ViewDEX 2.0 is a development of ViewDEX 1.0, which was released in 2007. Both
versions are designed to run in a Java environment and do not require any special installation. For example, the program
can be located on a memory stick or stand alone hard drive and be run from there. ViewDEX is managed and configured
by editing property files, which are plain text files where users, tasks (questions, definitions, etc.) and functionality
(WW/WL, PAN, ZOOM, etc.) are defined. ViewDEX reads all common DICOM image formats and the images can be
stored in any location connected to the computer. ViewDEX 2.0 is designed so that the user in a simple way can alter if
the questions presented to the observers are related to localization or not, enabling e.g. free-response ROC, standard
ROC and visual grading studies, as well as combinations of these, to be conducted in a fast and efficient way. The
software can also be used for bench marking and for educational purposes. The results from each observer are saved in a
log file, which can be exported for further analysis. The software is freely available for non-commercial purposes.
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