A simple scheme is proposed for generating frequency 16-tupling millimeter-wave (MMW) signal based on cascaded Mach–Zehnder modulators (MZMs) and an optical phase shifter (PS) without optical filter. Theoretical analysis is given to generate the high-quality 16-tupling MMW signal by eliminating the undesired optical carrier and sidebands. Simulations show that the generated 16-tupling optical MMW signal has the optical sideband suppression ratio higher than 29.85 dB and radio frequency (RF) spurious sideband suppression ratio higher than 23.9 dB. The impact of non-ideal modulation index, extinction ratio, and phase difference of optical PS- and RF-driven signal applied to the cascaded MZMs are discussed and analyzed. After different lengths of fiber transmission, the generated optical MMW signal shows good performance. Furthermore, the influence of different laser linewidths on the transmission performance of the generated MMW signal is also performed and analyzed.