Review of optical coherence tomography based angiography in neuroscience

Utku Baran; Ruikang K. Wang

doi:10.1117/1.NPh.3.1.010902

20 January 2016 Review of optical coherence tomography based angiography in neuroscience

Utku Baran, Ruikang K. Wang

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Neurophotonics, Vol. 3, Issue 1, 010902 (January 2016). https://doi.org/10.1117/1.NPh.3.1.010902

Abstract

The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution (∼10 μm) and without a need for contrast agents. Recent development of OCT-based angiography has started to shed some new light on cerebral hemodynamics in neuroscience. We give an overview of the recent developments of OCT-based imaging techniques for neuroscience applications in rodents. We summarize today’s technological alternatives for OCT-based angiography for neuroscience and provide a discussion of challenges and opportunities. Moreover, a summary of OCT angiography studies for stroke, traumatic brain injury, and subarachnoid hemorrhage cases on rodents is provided.

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Utku Baran and Ruikang K. Wang "Review of optical coherence tomography based angiography in neuroscience," Neurophotonics 3(1), 010902 (20 January 2016). https://doi.org/10.1117/1.NPh.3.1.010902

Published: 20 January 2016

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