In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties

Philippe Thueler; Igor Charvet; Frédéric P. Bevilacqua; Michel Saint Ghislain; G. Ory; Pierre Marquet; Paolo Meda; Ben Vermeulen; Christian D. Depeursinge

doi:10.1117/1.1578494

1 July 2003 In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties

Philippe Thueler, Igor Charvet, Frédéric P. Bevilacqua, Michel Saint Ghislain, G. Ory, Pierre Marquet, Paolo Meda, Ben Vermeulen, Christian D. Depeursinge

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Journal of Biomedical Optics, Vol. 8, Issue 3, (July 2003). https://doi.org/10.1117/1.1578494

A fast spectroscopic system for superficial and local determination of the absorption and scattering properties of tissue (480 to 950 nm) is described. The probe can be used in the working channel of an endoscope. The scattering properties include the reduced scattering coefficient and a parameter of the phase function called γ, which depends on its first two moments. The inverse problem algorithm is based on the fit of absolute reflectance measurements to cubic B-spline functions derived from the interpolation of a set of Monte Carlo simulations. The algorithm's robustness was tested with simulations altered with various amounts of noise. The method was also assessed on tissue phantoms of known optical properties. Finally, clinical measurements performed endoscopically in vivo in the stomach of human subjects are presented. The absorption and scattering properties were found to be significantly different in the antrum and in the fundus and are correlated with histopathologic observations. The method and the instrument show promise for noninvasive tissue diagnostics of various epithelia.

©(2003) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Philippe Thueler, Igor Charvet, Frédéric P. Bevilacqua, Michel Saint Ghislain, G. Ory, Pierre Marquet, Paolo Meda, Ben Vermeulen, and Christian D. Depeursinge "In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties," Journal of Biomedical Optics 8(3), (1 July 2003). https://doi.org/10.1117/1.1578494

Published: 1 July 2003

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