Development of a platform for broadband, spectra-fitted, tissue optical phantoms

Alec B. Walter; E. Duco Jansen

doi:10.1117/1.JBO.28.2.025001

20 February 2023 Development of a platform for broadband, spectra-fitted, tissue optical phantoms

Alec B. Walter, E. Duco Jansen

Author Affiliations +

Journal of Biomedical Optics, Vol. 28, Issue 2, 025001 (February 2023). https://doi.org/10.1117/1.JBO.28.2.025001

Abstract

Significance

Current methods of producing optical phantoms are incapable of accurately capturing the wavelength-dependent properties of tissue critical for many optical modalities.

Aim

We aim to introduce a method of producing solid, inorganic phantoms whose wavelength-dependent optical properties can be matched to those of tissue over the wavelength range of 370 to 950 nm.

Approach

The concentration-dependent optical properties of 20 pigments were characterized and used to determine combinations that result in optimal fits compared to the target properties over the full spectrum. Phantoms matching the optical properties of muscle and nerve, the diffuse reflectance of pale and melanistic skin, and the chromophore concentrations of a computational skin model with varying oxygen saturation (StO₂) were made with this method.

Results

Both optical property phantoms were found to accurately mimic their respective tissues’ absorption and scattering properties across the entire spectrum. The diffuse reflectance phantoms were able to closely approximate skin reflectance regardless of skin type. All three computational skin phantoms were found to have emulated chromophore concentrations close to the model, with an average percent error for the StO₂ of 4.31%.

Conclusions

This multipigment phantom platform represents a powerful tool for creating spectrally accurate tissue phantoms, which should increase the availability of standards for many optical techniques.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Alec B. Walter and E. Duco Jansen "Development of a platform for broadband, spectra-fitted, tissue optical phantoms," Journal of Biomedical Optics 28(2), 025001 (20 February 2023). https://doi.org/10.1117/1.JBO.28.2.025001

Received: 4 November 2022; Accepted: 24 January 2023; Published: 20 February 2023

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