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2 December 2023 Nanosecond multipulse retinal damage thresholds of elongated irradiance profiles in explant measurements and simulations
Marc Herbst, Sebastian Kotzur, Annette Frederiksen, Wilhelm Stork
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Journal of Biomedical Optics, Vol. 28, Issue 12, 125001 (December 2023). https://doi.org/10.1117/1.JBO.28.12.125001
Abstract

Significance

The database for multipulse retinal damage thresholds for the laser safety standard (IEC 60825-1:2014) is confined, especially for elongated irradiation profiles. To ensure eye safety, retinal damage thresholds (ED50 values) need to be determined.

Aim

This study aims to examine nanosecond multipulse scenarios.

Approach

To determine ED50 values in ex vivo measurements, an optical laser setup is presented. Porcine explant tissue is irradiated with rectangular top-hat profiles. Thermal simulations are carried out on a validated computer model and retinal injury thresholds are obtained.

Results

The measurements resulted in ED50 values from 8.46 to 42.72 μJ with a slope from 1.15 to 1.4. A thermal damage in the measurements can be excluded due to the level value in combination with a different type of declining behavior for increasing pulses compared to the simulations. A dependence with increasing elongation or area of the retinal image emerges in the simulations but could not be confirmed in the measurements due to the influencing factors (biological variability, focusing, and measuring procedure).

Conclusions

Using slit apertures for beam shaping, variable rectangular spot geometries are realized without changing elements in the setup. For further evaluation of the behavior of elongated irradiation profiles, additional measurements to improve the measurement accuracy are necessary.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Citation Download Citation
Marc Herbst, Sebastian Kotzur, Annette Frederiksen, and Wilhelm Stork "Nanosecond multipulse retinal damage thresholds of elongated irradiance profiles in explant measurements and simulations," Journal of Biomedical Optics 28(12), 125001 (2 December 2023). https://doi.org/10.1117/1.JBO.28.12.125001
Received: 21 June 2023; Accepted: 30 October 2023; Published: 2 December 2023
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KEYWORDS
Laser damage threshold
Biological samples
Tissues
Simulations
Laser safety
Explants
Laser irradiation
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