CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 28 > Issue 1 > Article
Open Access
18 January 2023 Noninvasive optical monitoring of pulmonary embolism: a Monte Carlo study on visible Chinese human thoracic tissues
Shuo Meng, Hengjie Su, Jianghui Guo, Lingxiao Wang, Ting Li
Author Affiliations +
Journal of Biomedical Optics, Vol. 28, Issue 1, 015001 (January 2023). https://doi.org/10.1117/1.JBO.28.1.015001
Abstract

Significance

In recent years, the incidence rate of pulmonary embolism (PE) has increased dramatically. Currently, the correct diagnosis rate of PE in China is relatively low, and the diagnosis error rate and missed diagnosis rate were as high as about 80%. The most standard method of PE detection is pulmonary artery digital subtraction angiography (DSA), but pulmonary artery DSA is an invasive examination, and patients can have certain risks and discomfort. Noninvasive monitoring of PE remains challenging in cardiovascular medicine.

Aim

We attempt to study the light propagation in human thoracic tissues and explore the possibility of near-infrared spectroscopy (NIRS) in noninvasive detection of PE.

Approach

In this study, by utilizing the Monte Carlo simulation method for voxelized media and the Visible Chinese Human dataset, we quantified and visualized the photon migration in human thoracic region. The influence of the development (three levels) of PE on the light migration was observed.

Results

Results showed that around 4.6% light fluence was absorbed by the pulmonary tissue. The maximum signal sensitivity distribution reached 0.073% at the 2.8- to 3.1-cm light source–detector separation. The normalized light intensity was significantly different among different PE levels and formed a linear relationship (r2 = 0.998, p < 10 − 5).

Conclusions

The study found that photons could reach the pulmonary artery tissue, the light intensity was linearly related to the degrees of embolism, PE could be quantitatively diagnosed by NIRS. Meanwhile, the optimized distance in between the light source and detector, 2.8 to 3.1 cm, was recommended to be used in future potential noninvasive optical diagnosis of PE.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Citation Download Citation
Shuo Meng, Hengjie Su, Jianghui Guo, Lingxiao Wang, and Ting Li "Noninvasive optical monitoring of pulmonary embolism: a Monte Carlo study on visible Chinese human thoracic tissues," Journal of Biomedical Optics 28(1), 015001 (18 January 2023). https://doi.org/10.1117/1.JBO.28.1.015001
Received: 28 June 2022; Accepted: 13 December 2022; Published: 18 January 2023
JOURNAL ARTICLE
 13 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 2 scholarly publications.
Advertisement
Advertisement
KEYWORDS
Tissues
Arteries
Monte Carlo methods
Blood
Near infrared spectroscopy
3D modeling
Tissue optics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top