Dermal fiber structures and photoaging

Jimmy Le Digabel; Sophia Houriez-Gombaud-Saintonge; Jérôme Filiol; Christophe Lauze; Gwendal Josse

doi:10.1117/1.JBO.23.9.096501

22 September 2018 Dermal fiber structures and photoaging

Jimmy Le Digabel, Sophia Houriez-Gombaud-Saintonge, Jérôme Filiol, Christophe Lauze, Gwendal Josse

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Journal of Biomedical Optics, Vol. 23, Issue 9, 096501 (September 2018). https://doi.org/10.1117/1.JBO.23.9.096501

Abstract

The use of multiphoton imaging has become a standard technique to visualize the dermis fibers as it requires no specific staining. The density and organization of collagen and elastin are common markers of skin intrinsic aging and photoaging; thus, there is a need of grading this skin aging with quantitative indicators able to provide a robust evaluation of the dermis fibers’ state. We propose a systematic analysis of multiphoton images of skin biopsies taken on the buttock and the forearm of patients of different ages. The intensity histograms of images were analyzed through their moments, a wavelet decomposition was done, and the wavelet coefficients distribution was fitted by a generalized Gaussian distribution. Different parameters relative to the collagen or elastin densities, organizations, and structures were calculated and exhibit phenomena specific to intrinsic or extrinsic aging. Those indicators could become a standard method to analyze the degree of skin aging (intrinsic or extrinsic) through multiphoton imaging.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jimmy Le Digabel, Sophia Houriez-Gombaud-Saintonge, Jérôme Filiol, Christophe Lauze, and Gwendal Josse "Dermal fiber structures and photoaging," Journal of Biomedical Optics 23(9), 096501 (22 September 2018). https://doi.org/10.1117/1.JBO.23.9.096501

Received: 7 March 2018; Accepted: 29 August 2018; Published: 22 September 2018

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