In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations

Stefan Kleiser; Daniel Ostojic; Nassim Nasseri; Helene Isler; Hans Ulrich Bucher M.D.; Dirk Bassler; Martin Wolf; Felix Scholkmann; Tanja Karen M.D.

doi:10.1117/1.JBO.23.6.067003

14 June 2018 In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations

Stefan Kleiser, Daniel Ostojic, Nassim Nasseri, Helene Isler, Hans Ulrich Bucher M.D., Dirk Bassler, Martin Wolf, Felix Scholkmann, Tanja Karen M.D.

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Journal of Biomedical Optics, Vol. 23, Issue 6, 067003 (June 2018). https://doi.org/10.1117/1.JBO.23.6.067003

Abstract

The aim was to determine the precision of a noninvasive near-infrared spectroscopy (NIRS)-based tissue oximeter (OxyPrem v1.3). Using a linear mixed-effects model, we quantified the variability for cerebral tissue oxygenation (StO2) measurements in 35 preterm neonates to be 2.64%, a value that meets the often-articulated clinicians’ demand for a precise tissue oxygenation measurement. We showed that the variability of StO2 values measured was dominated by spontaneous systemic hemodynamic fluctuations during the measurement, meaning that precision of the instrument was actually even better. Based on simultaneous and continuous measurements of peripheral arterial oxygenation and cerebral StO2 with a second sensor, we were able to determine and quantify the physiological instability precisely. We presented different methods and analyses aiming at reducing this systematic physiological error of in vivo precision assessments. Using these methods, we estimated the precision of the OxyPrem tissue oximeter to be ≤ 1.85 % . With our study, we deliver relevant information to establish highly precise cerebral oxygenation measurements with NIRS-based oximetry, facilitating the further development toward a substantially improved diagnosis and treatment of patients with respect to brain oxygenation.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Stefan Kleiser, Daniel Ostojic, Nassim Nasseri, Helene Isler, Hans Ulrich Bucher M.D., Dirk Bassler, Martin Wolf, Felix Scholkmann, and Tanja Karen M.D. "In vivo precision assessment of a near-infrared spectroscopy-based tissue oximeter (OxyPrem v1.3) in neonates considering systemic hemodynamic fluctuations," Journal of Biomedical Optics 23(6), 067003 (14 June 2018). https://doi.org/10.1117/1.JBO.23.6.067003

Received: 12 March 2018; Accepted: 21 May 2018; Published: 14 June 2018

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