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10 January 2018 Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses
Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, Lihong V. Wang
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Journal of Biomedical Optics, Vol. 23, Issue 1, 010501 (January 2018). https://doi.org/10.1117/1.JBO.23.1.010501
Abstract
Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications, which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded optical focusing in reflection mode, we focused 532-nm light through a highly scattering ex vivo adult human cataractous lens. This work demonstrates a potential clinical application of wavefront shaping techniques.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, and Lihong V. Wang "Time-reversed ultrasonically encoded optical focusing through highly scattering ex vivo human cataractous lenses," Journal of Biomedical Optics 23(1), 010501 (10 January 2018). https://doi.org/10.1117/1.JBO.23.1.010501
Received: 2 November 2017; Accepted: 1 December 2017; Published: 10 January 2018
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Cited by 10 scholarly publications and 1 patent.
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KEYWORDS
Wavefronts
Light scattering
Retina
Scattering
Spatial light modulators
Surgery
Ultrasonics
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