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15 September 2017 Luminescent diagnostics of skin defects in the near-infrared range
Yuri V. Alekseev, Valentina D. Rumyantseva, Anastasiya S. Gorshkova, Anastasiya E. Shchelkunova, Igor P. Shilov, Andrey V. Ivanov
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Journal of Biomedical Optics, Vol. 22, Issue 9, 098001 (September 2017). https://doi.org/10.1117/1.JBO.22.9.098001
Abstract
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Yuri V. Alekseev, Valentina D. Rumyantseva, Anastasiya S. Gorshkova, Anastasiya E. Shchelkunova, Igor P. Shilov, and Andrey V. Ivanov "Luminescent diagnostics of skin defects in the near-infrared range," Journal of Biomedical Optics 22(9), 098001 (15 September 2017). https://doi.org/10.1117/1.JBO.22.9.098001
Received: 1 June 2017; Accepted: 21 August 2017; Published: 15 September 2017
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KEYWORDS
Luminescence
Diagnostics
Ytterbium
Skin
Tissues
Tumors
Ions
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